C57BL/6NTac-Casrem1H/H

Status

Available to order

EMMA IDEM:15119
International strain nameC57BL/6NTac-Casrem1H/H
Alternative nameCASR-MSCARLET-EM1-B6N
Strain typeEndonuclease-mediated
Allele/Transgene symbolCasrem1H
Gene/Transgene symbolCasr

Information from provider

Provider MRC-Harwell
Provider affiliationMammalian Genetics Unit, Mary Lyon Centre at MRC Harwell
Genetic informationFor detailed information on the genetic description of this strain, please have a look at this report.
Breeding historyCo-isogenic on original background
ReferencesNone available
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requirednot known
Immunocompromisednot known

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • increased circulating calcium level / IMPC
  • decreased prepulse inhibition / IMPC
  • edema / IMPC
  • abnormal pancreas morphology / IMPC
  • small superior vagus ganglion / IMPC
  • increased circulating phosphate level / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • enlarged uterus / IMPC
MGI phenotypes (gene matching)
  • delayed bone ossification / MGI
  • decreased bone mineral density / MGI
  • kyphoscoliosis / MGI
  • increased circulating calcium level / MGI
  • decreased circulating calcium level / MGI
  • decreased circulating phosphate level / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • cataract / MGI
  • dehydration / MGI
  • aphagia / MGI
  • abnormal posture / MGI
  • increased circulating phosphate level / MGI
  • postnatal growth retardation / MGI
  • abnormal coat/hair pigmentation / MGI
  • premature death / MGI
  • increased hematocrit / MGI
  • abnormal bone mineralization / MGI
  • decreased urine phosphate level / MGI
  • increased circulating parathyroid hormone level / MGI
  • decreased circulating parathyroid hormone level / MGI
  • abnormal postural reflex / MGI
  • decreased urine calcium level / MGI
  • enlarged parathyroid gland / MGI
  • pigmented parathyroid gland / MGI
  • rickets / MGI
  • calcinosis / MGI
  • nephrocalcinosis / MGI
  • calcified muscle / MGI
  • increased width of hypertrophic chondrocyte zone / MGI
  • parathyroid gland hyperplasia / MGI
  • lethargy / MGI
  • renal/urinary system phenotype / MGI
  • growth/size/body region phenotype / MGI
  • endocrine/exocrine gland phenotype / MGI
  • skeleton phenotype / MGI
  • hematopoietic system phenotype / MGI
  • increased circulating magnesium level / MGI
  • postnatal lethality, complete penetrance / MGI
  • abnormal parathyroid gland chief cell morphology / MGI
  • tongue inflammation / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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