129-Il1rl1tm1Brl/ZbzCnrm

Status

Available to order

EMMA IDEM:00002
International strain name129-Il1rl1tm1Brl/ZbzCnrm
Alternative name129TgH(GS-T1)Brl
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolIl1rl1tm1Brl,
Gene/Transgene symbolIl1rl1

Information from provider

ProviderKarin Senn
Provider affiliationInstitute of Experimental Immunology, Institute of Experimental Immunology
Genetic informationDeletion of Il1rl1 (T1/ST2) gene; mice express the lacZ gene under the T1/ST2 promoter.
Phenotypic informationFor mast cells and T helper 2 (Th2) cells no phenotypic alterations found so far; functional properties under investigation.
References
  • T1-deficient and T1-Fc-transgenic mice develop a normal protective Th2-type immune response following infection with Nippostrongylus brasiliensis.;Senn K A, McCoy K D, Maloy K J, Stark G, Fröhli E, Rülicke T, Klemenz R, ;2000;European journal of immunology;30;1929-38; 10940882

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy
Animals used for archivinghomozygous 129S/SvEv (synonyms: 129/SvEv or 129S), wild-type 129S/SvEv (synonyms: 129/SvEv or 129S)
Stage of embryos8-cell

Disease and phenotype information

MGI phenotypes (allele matching)
  • increased eosinophil cell number / MGI
  • abnormal response to infection / MGI
  • decreased interleukin-5 secretion / MGI

Literature references

  • T1-deficient and T1-Fc-transgenic mice develop a normal protective Th2-type immune response following infection with Nippostrongylus brasiliensis.;Senn K A, McCoy K D, Maloy K J, Stark G, Fröhli E, Rülicke T, Klemenz R, ;2000;European journal of immunology;30;1929-38; 10940882

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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