IPAD-MD

IPAD-MD project (Research Infrastructure for Phenotyping, Arching and Distribution of Mouse Diseases Models)  addresses the global cooperation and coordination between INFRAFRONTIER and complementary research infrastructures world-wide, contributing to the global effort of IMPC. IPAD-MD will focus on key stakeholder involvement.

IPAD-MD organizes a series of workshops aiming at:

  • Improving access to common  INFRAFRONTIER and IMPC resources
  • Aligning scientific strategy with international research agendas
  • Engaging key stakeholders to improve INFRAFRONTIER and IMPC resources and services
  • Coordinating globally the development of innovative technology solutions
Topics
 

IPAD-MD Topics

Topic I. Global Access to Common Resources
Keywords: MTAs, IP and licensing models, repositories sustainable funding, material shipping issues, standards & nomenclature   

Topic II. Key Stakeholder Engagement
Keywords: Resource usability, (priorisation) mouse disease models, visibility of resources and services

Topic III. Innovative Technology Solutions
Keywords: (optimisation) existing pipelines, common standards, reliability and interoperability, big data & data services

 

Cross-cutting themes

Animal welfare
Outreach to Africa
Communications & Dissemination

Stakeholders Meetings

2015: Kick-Off meeting, July 21-22, Munich, Germany

Agenda & Minutes

IPAD-MD KO 07.2015

 

2016: Industry & Innovation Worskhop, 28-29 June, Munich, Germany 

Agenda & List of Participants (17.06.2016) 

Abstract Book (16.06.2016)

Exhibition area  - Floor plan (20.06.2016)

Practical Information

Industry & Innovation Workshop Report (D2.1; 28.06.2016)

IPAD-MD I&I WS 2016

 

Literature collection to support the panel discussions

Panel 1: Impact of CRISPR technology on repositories, IT & animal welfare

Doudna & Charpentier. 2014. Genome editing The new frontier of genome engineering with CRISPR-Cas9 PMID: 25430774

Dow. 2015. Modeling Disease In Vivo with CRISPR/Cas9. PMID: 26432018  

Hsu et al. 2014. Development and applications of CRISPR-Cas9 for genome engineering.PMID: 24906146 

Ledford. 2015. CRISPR, the disruptor. PMID: 26040877

 

Panel 2: Impact of rodents as model of human diseases

Collins & Tabak. 2014. NIH  plans to enhance reproducibitlity. PMID: 24482835

Everitt. 2014. The future of preclinical animal models in pharmaceutical discovery and developments: a need to bring in cerebro to the in vivo discussions PMID: 25351920

Ioannidis JPA. 2014. How to make more published research true PMID: 25334033

Justice & Dhilon. 2016. Using the mouse to model human disease: increasing validity and reproducibility. PMID: 26839397

Macleod et al  2014. Biomedical research: increasing value, reducing waste PMID: 24411643

Perrin. 2014. Make mouse studies work. PMID: 24678540

Prinz et al., 2011. Believe it or not: how much can we rely on published data on potential drug targets? PMID: 21892149

Steckler. 2015. Preclinical data reproducibility for R&D - the challenge for neuroscience. PMID: 25585680 

Vandamme. 2015. Rodent models for human diseases. PMID: 25823811

van der Worp et al., 2010. Can animal models of disease reliably inform human studies? PMID: 20361020 

Expert Group Meetings

2015

Standards & Technology Expert Group Meeting - Phenotyping, September 14-15, Seoul, Korea  & Archiving, November 18, Rome, Italy

Meeting report  (D6.1, 11.12.2015)

Data & Resources Expert Group Meeting, October 27-28, Hinxton, UK

Meeting report  (D7.1, 01.12.2015) 

 IPAD-MD WS D&R 10.2015

2016

Standards & Technology Expert Group Meeting (WP6) : 'Genome Editing Workshop' at  IMPC - INFRAFRONTIER Strasbourg meeting, 20-22 April 2016

Meeting report  (D6.2, 20.04.2016)

Data & Resources Expert Group Meeting (WP7): Improving Curation and Annotation Tooling for Animal Models of Rare Disease, 08-09 December 2016, Freising, Germany

Workshop goals

  1. Facilitate communication between curators that have an interest in annotating animal models of human disease
  2. Discuss the strengths and weaknesses of curatorial resources (ontologies, tools, etc)
  3. Investigate synergies between groups to accelerate annotation of rare disease models

Meeting report  (D7.2, 08.12.2016)

Work Packages & Project Deliverables

Work package 1 - Management

D1.1: Minutes  Kick-Off Meeting (27.08.2015)

Work package 2 -  Coordination & Workshop organisation

D2.1: Report on Stakeholder Engagement Meeting - Industry & Innovation Workshop (28.06.2016)

Work package 3 - Engagement with Funders & Policy

D3.1: Survey on European and International Research Agendas (22.12.2015)

Work package 4 - Engagement with Users & Industry

D4.1: Survey on user requirements and application scenarios for mouse resources and data (12.06.2016)

Work package 5 - Engagement with Patient Organisations

D5.1: Survey on Patient Organization Research Agendas

Work package 6 - Implementing Standards & Technology

D6.1: Report on Standards & Technology Expert Group Meeting (11.12.2015)

D6.2: Report on Standards & Technology Expert Group Meeting (20.04.2016)

Work package 7 - Access to Data & Standards

D7.1: Report on Data & Resources Expert Group Meeting (21.12.2015)

D7.2: Report on Data & Resources Expert Group Meeting (08.12.2016)

Work package 8 - Animal Welfare

IPAD-MD  has received funding  from European Union's Horizon 2020 research and innovation programme under Grant Agreement number 653961.