Mouse as model of human diseases

Adissu et al., 2014. Histopathology reveals correlative and unique phenotypes in high-throughput mouse phenotyping

Doyle et al., 2012. Reconstruction of transgenic and gene knockout and knockin mouse models of human diseases. Transgenic Research 21: 327-349

Justice et al., 2011. Technical approaches of mouse model of human diseases. Disease Models & Mechanisms 4:305-310

Ageing

Duran et al., 2013. ShARM:  A new facilty to facilitate ageing research. Biogerontology 14: 789-794 

Yuan et al., 2011. Mice as a mammalian model for research on genetics of Ageing. ILAR 52:4-15

Liao et al., 2010. Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening. Aging Cell 9: 92-95 

Cancer

Drost & Jonkers. 2014.  Opportunities and hurdles in the treatment of BRCA1-related breast cancer. Oncogene 33:3753-3763.

Drost & Jonkers. 2009. Preclinical mouse models for BRCA1-associated breast cancer. Br J Cancer. 101:1651-1657

Nardella et al., 2011. The APL paradigm and the 'co-clinical trial' project. Cancer Discov. 1: 108-116

Cardiovascular

Koutnikova et al., 2009. Identification of the UBP1 locus as a critical blood pressure determinant using a combination of mouse and human genetics. Plos Gen. 5:e1000591

Wang et al., 2005. Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility. Nature Genet. 37:365-372

Drug discovery

Baldarelli 2012. Drug discovery: In defense of animal model. Nature 485: 309

Zambrowicz & Sands 2003. Knockout models the 100 best-selling drugs - will they model the next 100? Nature 2: 38-51

Infection & Immunology

Davis 2012. Immunology taught by humans. Sci Transl. Med. 18:117

Lim & Shin. 2013. West Nile virus discovery. Viruses 52977-3006.

Lim et al., 2009. Genetic variation of OAS1 is a risk factor for initial infection with West Nile virus in man. PLOS Pathol. e1000321. 

Smilek et al., 2014. Restoring the balance: immunotherapeutic combinations for autoimmune disease. Dis Model Mech.7: 503-5013

Yakub et al., 2005. Single nucleotide polymorphisms in genes for 2'-5'-oligoadenylate synthetase and RNase L inpatients hospitalized with West Nile virus infection.J Infect Dis. 192:1741-1748.

Metabolism, Diabetes, Obesity

Bar et al., 2010. Liquid chromatography-mass spectrometry-based parallel metabolic profiling of human and mouse serum reveals putative biomarkers with the progression of nonalcoholic fatty liver diseases. J. Proteome Res. 9:4501

Friedmann & Halaas 1998. Leptin and the regulation of body weight in mammals. Nature 387:903-908

Von Herrath & Nepom, 2009. Autoimune Disease: type 1 diabetes – Remodeling rodent models to mimic type 1 diabetes. Eur. J. Immunol. 39: 2049-2058

Neurology

Nardella et al., 2011. The APL paradigm and the 'co-clinical trial' project. Cancer Discov. 1: 108-116

Report of the JPND Action Group. 2014. Experimental models for neurodegenerative diseases. EU Joint Programme – Neurodegenerative Disease Research 43 pp.

Rare Diseases

Chao & Zoghi. 2012. MeCP2: only 100% will do. Nature  Neuroscience15:176-177

Vaquer G et al., 2013. Animal models for metabolic, neuromuscular and ophthalmological rare diseases. Nature Reviews - Drug Discovery 12: 287-305.

Bakhle 2004. Missing evidence that animal research benefits humans: evidence is all around us. BMJ 328:1017

Collins et al. 2007. A Mouse for all reasons. Cell 128: 9-13

Cressey 2015. UK funders demand strong statistics for animal studies. Nature 520: 271-272

Demengeot et al., 2014. Science with a conscience. Pan European Networks: Science & Technology 11:1-4

Perrin 2014. Pre clinical research: make animal models work. Nature 507:423-425

Pound et al., 2004. Where is the evidence that animal research benefits humans? BMJ 328: 514-517

Rosenthal & Brown 2007. The mouse ascending: perspectives for human disease models. Nature Cell Biol. 9:993-999

Schughart et al., 2012. Strength to strength for mouse models. Nature 492: 41

Schughart et al., 2013. Controlling complexity: the clinical relevance of mouse complex genetics Eur. J. Hum. Gen. 1-6

Baldarelli. 2012. In defense of the animal model. Nature 485:309

Aigner et al., 2010. Transgenic pigs as models for translational biomedical research. J Mol Med. 88: 653-664.

Bolker 2012. There is more to life than rats and flies. Nature 431: 31-33

Dhillon 2013. Building bridges with zebrafish: highlights of the 'Zebrafish Models in Translational Medicine Meeting'. Dis Model Mech. 3: 1301-1302.

Luo et al., 2012. Genetically modified pigs for biomedical research. J. Inherit Metab. Dis. 3:695-713

Schartl 2014. Beyond zebrafish: diverse fish species for modeling human disease. Dis Model Mech. 7: 181–192

Seth et al., 2013. The emerging use of zebrafish to model metabolic disease. Dis Model Mech. 6: 1080-1088

Carninci P. 2014. Mice in the ENCODE spotlight. Nature 515:346-347

Cheng et al. 2014. Principles of regulatory information between mouse and human. Nature 515:371-387

Knight 2008. Systematic reviews on animal experiments demonstrate poor contribution towards human health care. Reviews on Recent Clinical Trials 3:89-96

Seok et al., 2013. Genomic responses in mouse models poorly mimics inflammatory disease. PNAS110: 3507-3512

Varga et al., 2010. Validating animal models for preclinical research: A scientific and ethical discussion. ATLA 38: 245-248

Van der Worp et al., 2010. Can animal models of diseases reliably inform human studies? PLoS Medicine 7 e: 1000245

Yue et al., 2014. A comparative encyclopaedia of DNA element in the mouse genome. Nature 515: 355-364