Mouse as model of human diseases

Default Title
Research Publications


Duran et al., 2013. ShARM:  A new facilty to facilitate ageing research. Biogerontology 14: 789-794 

Yuan et al., 2011. Mice as a mammalian model for research on genetics of Ageing. ILAR 52:4-15

Liao et al., 2010. Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening. Aging Cell 9: 92-95 


Drost & Jonkers. 2014.  Opportunities and hurdles in the treatment of BRCA1-related breast cancer. Oncogene 33:3753-3763.

Drost & Jonkers. 2009. Preclinical mouse models for BRCA1-associated breast cancer. Br J Cancer. 101:1651-1657

Nardella et al., 2011. The APL paradigm and the 'co-clinical trial' project. Cancer Discov. 1: 108-116


Koutnikova et al., 2009. Identification of the UBP1 locus as a critical blood pressure determinant using a combination of mouse and human genetics. Plos Gen. 5:e1000591

Wang et al., 2005. Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility. Nature Genet. 37:365-372

Drug discovery

Baldarelli 2012. Drug discovery: In defense of animal model. Nature 485: 309

Zambrowicz & Sands 2003. Knockout models the 100 best-selling drugs - will they model the next 100? Nature 2: 38-51

Infection & Immunology

Davis 2012. Immunology taught by humans. Sci Transl. Med. 18:117

Lim & Shin. 2013. West Nile virus discovery. Viruses 52977-3006.

Lim et al., 2009. Genetic variation of OAS1 is a risk factor for initial infection with West Nile virus in man. PLOS Pathol. e1000321. 

Smilek et al., 2014. Restoring the balance: immunotherapeutic combinations for autoimmune disease. Dis Model Mech.7: 503-5013

Yakub et al., 2005. Single nucleotide polymorphisms in genes for 2'-5'-oligoadenylate synthetase and RNase L inpatients hospitalized with West Nile virus infection.J Infect Dis. 192:1741-1748.


Metabolism, Diabetes, Obesity

Bar et al., 2010. Liquid chromatography-mass spectrometry-based parallel metabolic profiling of human and mouse serum reveals putative biomarkers with the progression of nonalcoholic fatty liver diseases. J. Proteome Res. 9:4501

Friedmann & Halaas 1998. Leptin and the regulation of body weight in mammals. Nature 387:903-908

Von Herrath & Nepom, 2009. Autoimune Disease: type 1 diabetes – Remodeling rodent models to mimic type 1 diabetes. Eur. J. Immunol. 39: 2049-2058


Nardella et al., 2011. The APL paradigm and the 'co-clinical trial' project. Cancer Discov. 1: 108-116

Report of the JPND Action Group. 2014. Experimental models for neurodegenerative diseases. EU Joint Programme – Neurodegenerative Disease Research 43 pp.

Rare Diseases

Chao & Zoghi. 2012. MeCP2: only 100% will do. Nature  Neuroscience15:176-177

Vaquer G et al., 2013. Animal models for metabolic, neuromuscular and ophthalmological rare diseases. Nature Reviews - Drug Discovery 12: 287-305.