The EMMA strain search outcomes are enriched by phenotypic annotations from external resouces. A brief summary list as well as a source linkage for each annotation is provided as part of the search result.
Mouse Genome Informatics (MGI)
MGI is the international database resource for the laboratory mouse, providing integrated genetic, genomic, and biological data to facilitate the study of human health and disease.
INFRAFRONTIER utilizes MGI data to highlight their annotated disease models in our strain search.
International Mouse Phenotype Consortium (IMPC)
The IMPC is a federation of phenotyping projects to carry out systemic phenotyping of mouse lines for each of the approximately 20.000 protein-coding genes in the mammalian genome in order to create an encyclopaedia of mammalian gene function. Systematic broad-based phenotyping is performed by each IMPC center using standardized procedures found within the International Mouse Phenotyping Resource of Standardised Screens (IMPReSS) resource. Gene-to-phenotype associations are made by a versioned statistical analysis with all data freely available.
INFRAFRONTIER incorporates IMPC phenotype and disease annotations to provide rich information for mice available at our repository.
Online Mendelian Inheritance in Man (OMIM)
OMIM is a comprehensive, authoritative compendium of human genes and genetic phenotypes. It focuses on the relationship between phenotype and genotype for all known mendelian disorders and over 15,000 genes.
INFRAFRONTIER uses OMIM to show MGI annotated disease models and provide links to the specific disease.
Disease Ontology (DO)
The Disease Ontology has been developed as a standardized ontology for human disease with the purpose of providing the biomedical community with consistent, reusable and sustainable descriptions of human disease terms, phenotype characteristics and related medical vocabulary disease concepts.
We use the DO terms to enable browsing of MGI curated mouse disease models in the INFRAFRONTIER search interface.