C3;C-Jag1Slalom/H

Status

Available to order

EMMA IDEM:00081
International strain nameC3;C-Jag1Slalom/H
Alternative nameGENA158
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolJag1Slalom,
Gene/Transgene symbolJag1

Information from provider

ProviderPat Nolan
Provider affiliationMRC Mammalian Genetics Unit
Genetic informationA C to T missense mutation causes a proline to serine change at conserved codon 269 in the second epidermal growth factor (EGF)-like repeat.
Phenotypic informationThese mice exhibit head weaving and shaking behaviour.
References
  • A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.;Nolan P M, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray I C, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson J A, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel K P, Voegeling S, Guenet J L, Nickols C, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher E M, Martin J, Rastan S, Brown S D, Hunter J, ;2000;Nature genetics;25;440-3; 10932191

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • hemorrhage / MGI
  • abnormal vitelline vasculature morphology / MGI
  • embryonic lethality during organogenesis / MGI
  • embryo tissue necrosis / MGI
  • abnormal semicircular canal morphology / MGI
  • head shaking / MGI
  • abnormal cochlear sensory epithelium morphology / MGI
  • increased cochlear inner hair cell number / MGI
  • decreased cochlear outer hair cell number / MGI
  • positive geotaxis / MGI
  • abnormal semicircular canal ampulla morphology / MGI
  • abnormal neural tube morphology / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI

Literature references

  • A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.;Nolan P M, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray I C, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson J A, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel K P, Voegeling S, Guenet J L, Nickols C, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher E M, Martin J, Rastan S, Brown S D, Hunter J, ;2000;Nature genetics;25;440-3; 10932191

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
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Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

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