STOCK Tg(Mbp-PDGFB)90Ubc/Kieg
Status | Available to order |
EMMA ID | EM:00134 |
International strain name | STOCK Tg(Mbp-PDGFB)90Ubc/Kieg |
Alternative name | MBP-PDGF B, MBP-PDGFB |
Strain type | Transgenic Strains |
Allele/Transgene symbol | Tg(Mbp-PDGFB)90Ubc, |
Gene/Transgene symbol | Tg(Mbp-PDGFB)90Ubc |
Information from provider
Provider | Karin Forsberg-Nilsson |
Provider affiliation | Department of Medical Biochemistry and Microbiology, Department of Medical Biochemistry and Microbiology |
Phenotypic information | Homozygous mice breed poorly. Increase in number of oligodendrocytes and astrocytes in white matter tracts that seem to normalize in adult life. Disorganized retinal cell layers, disorganized retinal capillary network. |
References |
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Information from EMMA
Archiving centre | Karolinska Institutet, Stockholm, Sweden |
Literature references
- Oligodendrocyte precursor hypercellularity and abnormal retina development in mice overexpressing PDGF-B in myelinating tracts.;Forsberg-Nilsson Karin, Erlandsson Anna, Zhang Xiao-Qun, Ueda Hideho, Svensson Kristian, Nistér Monica, Trapp Bruce D, Peterson Alan C, Westermark Bengt, ;2003;Glia;41;276-89; 12528182
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