B6.129P2-Gja1tm5(cre/ERT)Kwi/Cnrm
| Status | Available to order |
| EMMA ID | EM:00330 |
| International strain name | B6.129P2-Gja1tm5(cre/ERT)Kwi/Cnrm |
| Alternative name | Cx43-KI-CreER(T) |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Gja1tm5(cre/ERT)Kwi, |
| Gene/Transgene symbol | Gja1 |
Information from provider
| Provider | Klaus WILLECKE |
| Provider affiliation | Molekulargenetik, Institut fuer Genetik, Universitaet Bonn |
| Genetic information | Exon 2, including the whole open reading frame of Cx43 (Gja1), is homologously replaced by the coding region of a fusion protein made of a modified estrogen receptor and cre recombinase. No selection marker is in the genome of the mice. |
| Phenotypic information | None. |
| Breeding history | After blastocyst injection the chimeras were bred with C57BL/6NCrl to obtain brown coat coloured offspring. This brown offspring was backcrossed to C57BL/6NCrl more than three times. |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
| Breeding at archiving centre | Backcrossed to C57BL/6J |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal dominant palmoplantar keratoderma and congenital alopecia / Orphanet_1010
- Oculodentodigital dysplasia / Orphanet_2710
- Craniometaphyseal dysplasia / Orphanet_1522
- Syndactyly type 3 / Orphanet_93404
- Erythrokeratodermia variabilis / Orphanet_317
Literature references
- Altered connexin expression and wound healing in the epidermis of connexin-deficient mice.;Kretz Markus, Euwens Carsten, Hombach Sonja, Eckardt Dominik, Teubner Barbara, Traub Otto, Willecke Klaus, Ott Thomas, ;2003;Journal of cell science;116;3443-52; 12840073
- Identification of Lgr5-independent spheroid-generating progenitors of the mouse fetal intestinal epithelium.;Mustata Roxana C, Vasile Gabriela, Fernandez-Vallone Valeria, Strollo Sandra, Lefort Anne, Libert Frédérick, Monteyne Daniel, Pérez-Morga David, Vassart Gilbert, Garcia Marie-Isabelle, ;2013;Cell reports;5;421-32; 24139799
- Trop2 marks transient gastric fetal epithelium and adult regenerating cells after epithelial damage.;Fernandez Vallone Valeria, Leprovots Morgane, Strollo Sandra, Vasile Gabriela, Lefort Anne, Libert Frederick, Vassart Gilbert, Garcia Marie-Isabelle, ;2016;Development (Cambridge, England);143;1452-63; 26989172