B6.129-Apoetm1Unc Tcrdtm1Mom/Orl

Status

Available to order

EMMA IDEM:00395
International strain nameB6.129-Apoetm1Unc Tcrdtm1Mom/Orl
Alternative nameapolipoprotein E KO and TCRdeltaKO
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolTcrdtm1Mom,
Gene/Transgene symbolTcrd

Information from provider

ProviderElhage R, Bayard F, Arnal JF
Provider affiliationINSERM U589 , CHU Rangueil
Genetic informationApolipoprotein E and TCRdelta double knock-out.
Phenotypic informationApolipoprotein E and T lymphocytes gamma/delta.
Breeding historyC57BL/6 background.
ReferencesNone available

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (allele matching)
  • increased circulating LDL cholesterol level / IMPC
  • increased circulating triglyceride level / IMPC
  • increased circulating free fatty acid level / IMPC
  • abnormal tooth morphology / IMPC
  • decreased erythrocyte cell number / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • increased circulating cholesterol level / IMPC
  • increased circulating bilirubin level / IMPC
  • decreased circulating serum albumin level / IMPC
  • decreased circulating glucose level / IMPC
  • decreased circulating sodium level / IMPC
  • increased mean corpuscular hemoglobin concentration / IMPC
MGI phenotypes (allele matching)
  • xanthoma / MGI
  • increased circulating cholesterol level / MGI
  • increased circulating triglyceride level / MGI
  • abnormal cochlea morphology / MGI
  • organ of Corti degeneration / MGI
  • abnormal stria vascularis morphology / MGI
  • increased bone mineral density / MGI
  • abnormal circulating cholesterol level / MGI
  • increased circulating LDL cholesterol level / MGI
  • decreased circulating HDL cholesterol level / MGI
  • decreased hematocrit / MGI
  • abnormal blood flow velocity / MGI
  • abnormal blood vessel physiology / MGI
  • abnormal liver physiology / MGI
  • abnormal immune system morphology / MGI
  • skin lesions / MGI
  • decreased body length / MGI
  • decreased body weight / MGI
  • abnormal spatial learning / MGI
  • abnormal skeleton physiology / MGI
  • hyperlipidemia / MGI
  • increased circulating HDL cholesterol level / MGI
  • cardiac hypertrophy / MGI
  • abnormal immune system physiology / MGI
  • vascular inflammation / MGI
  • abnormal lung volume / MGI
  • deafness / MGI
  • premature death / MGI
  • abnormal pulmonary alveolus morphology / MGI
  • increased immunoglobulin level / MGI
  • increased IgM level / MGI
  • decreased circulating triglyceride level / MGI
  • abnormal immune serum protein physiology / MGI
  • increased thigmotaxis / MGI
  • increased heart weight / MGI
  • cochlear ganglion degeneration / MGI
  • abnormal tectorial membrane morphology / MGI
  • impaired muscle relaxation / MGI
  • increased cholesterol efflux / MGI
  • increased cardiac output / MGI
  • oxidative stress / MGI
  • increased autoantibody level / MGI
  • abnormal retinal inner nuclear layer morphology / MGI
  • abnormal bone structure / MGI
  • arteriosclerosis / MGI
  • increased compact bone thickness / MGI
  • abnormal basilar membrane morphology / MGI
  • cochlear inner hair cell degeneration / MGI
  • cochlear outer hair cell degeneration / MGI
  • abnormal spiral modiolar artery morphology / MGI
  • spiral modiolar artery stenosis / MGI
  • increased anti-double stranded DNA antibody level / MGI
  • increased anti-nuclear antigen antibody level / MGI
  • increased susceptibility to systemic lupus erythematosus / MGI
  • decreased systemic vascular resistance / MGI
  • increased spleen weight / MGI
  • abnormal osteoblast physiology / MGI
  • increased B cell number / MGI
  • increased circulating VLDL cholesterol level / MGI
  • abnormal blood-brain barrier function / MGI
  • abnormal renal glomerulus morphology / MGI
  • atherosclerotic lesions / MGI
  • increased susceptibility to atherosclerosis / MGI
  • decreased susceptibility to atherosclerosis / MGI
  • vascular stenosis / MGI
  • increased susceptibility to weight gain / MGI
  • abnormal eye electrophysiology / MGI
  • decreased circulating glucose level / MGI
  • abnormal enzyme/coenzyme activity / MGI
  • decreased vasodilation / MGI
  • decreased susceptibility to type IV hypersensitivity reaction / MGI
  • abnormal circulating homocysteine level / MGI
  • abnormal T cell number / MGI
  • abnormal CD4-positive, alpha beta T cell number / MGI
  • increased T-helper 2 cell number / MGI
  • decreased follicular B cell number / MGI
  • increased marginal zone B cell number / MGI
  • decreased marginal zone B cell number / MGI
  • abnormal B cell activation / MGI
  • thin retinal inner nuclear layer / MGI
  • thin retinal outer nuclear layer / MGI
  • impaired olfaction / MGI
  • decreased interferon-gamma secretion / MGI
  • abnormal aorta wall morphology / MGI
  • kidney microaneurysm / MGI
  • increased bone trabecula number / MGI
  • increased lung compliance / MGI
  • increased airway resistance / MGI
  • abnormal lung hysteresivity / MGI
  • abnormal kidney arterial blood vessel morphology / MGI
  • expanded mesangial matrix / MGI
  • mesangiolysis / MGI
  • glomerular capillary thrombosis / MGI
  • dilated glomerular capillary / MGI
  • renal glomerulus lipidosis / MGI
  • increased cardiac stroke volume / MGI
  • increased or absent threshold for auditory brainstem response / MGI
  • abnormal adrenal gland morphology / MGI
  • increased anxiety-related response / MGI
  • abnormal locomotor behavior / MGI
  • abnormal response to new environment / MGI
  • decreased exploration in new environment / MGI
  • decreased startle reflex / MGI
  • abnormal kindling response / MGI
  • abnormal lipid level / MGI
  • hypersecretion of corticosterone / MGI
  • abnormal gland physiology / MGI
  • abnormal dendritic cell physiology / MGI
  • abnormal cell-mediated immunity / MGI
  • abnormal sciatic nerve morphology / MGI
  • abnormal thermal nociception / MGI
  • hypopituitarism / MGI
  • abnormal myelin sheath morphology / MGI
  • abnormal synaptic vesicle morphology / MGI
  • increased susceptibility to parasitic infection / MGI
  • decreased circulating leptin level / MGI
  • increased CD4-positive, alpha beta T cell number / MGI
  • abnormal adrenal cortex morphology / MGI
  • abnormal adrenal medulla morphology / MGI
  • decreased epididymal fat pad weight / MGI
  • increased food intake / MGI
  • increased fluid intake / MGI
  • decreased brown adipose tissue mass / MGI
  • increased startle reflex / MGI
  • increased circulating corticosterone level / MGI
  • altered susceptibility to atherosclerosis / MGI
  • decreased cerebral infarction size / MGI
  • abnormal dendrite morphology / MGI
  • lung inflammation / MGI
  • abnormal astrocyte physiology / MGI
  • abnormal synapse morphology / MGI
  • increased prostaglandin level / MGI
  • abnormal lipid homeostasis / MGI
  • increased circulating phospholipid level / MGI
  • abnormal cholesterol homeostasis / MGI
  • abnormal circulating protein level / MGI
  • decreased vertical activity / MGI
  • nervous system phenotype / MGI
  • behavior/neurological phenotype / MGI
  • abnormal respiratory system physiology / MGI
  • abnormal skin condition / MGI
  • dermatitis / MGI
  • impaired skin barrier function / MGI
  • increased susceptibility to type IV hypersensitivity reaction / MGI
  • immune system phenotype / MGI
  • increased apoptosis / MGI
  • integument phenotype / MGI
  • absent gamma-delta T cells / MGI
  • abnormal gamma-delta T cell differentiation / MGI

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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