STOCK Myo7a4626SB/NihrH

Status

Available to order

EMMA IDEM:00442
International strain nameSTOCK Myo7a4626SB/NihrH
Alternative nameMyo7a
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolMyo7a4626SB,
Gene/Transgene symbolMyo7a

Information from provider

ProviderKaren Steel
Provider affiliationWellcome Trust Sanger Institute
Phenotypic informationMice homozygous for this mutation exhibit almost constant circling behaviour and show no Preyer reflex. Heterozygotes and wild-types are indistinguishable.
References
  • A Myo7a mutation cosegregates with stereocilia defects and low-frequency hearing impairment.;Rhodes Charlotte R, Hertzano Ronna, Fuchs Helmut, Bell Rachel E, de Angelis Martin Hrabé, Steel Karen P, Avraham Karen B, ;2004;Mammalian genome : official journal of the International Mammalian Genome Society;15;686-97; 15389316

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

MGI allele-associated human disease models

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • decreased cochlear outer hair cell number / MGI
  • abnormal cochlear nerve compound action potential / MGI
  • abnormal outer hair cell stereociliary bundle morphology / MGI
  • decreased outer hair cell stereocilia number / MGI
  • increased susceptibility to age-related hearing loss / MGI
  • impaired hearing / MGI
  • abnormal cochlear outer hair cell morphology / MGI
  • cochlear outer hair cell degeneration / MGI
  • short cochlear outer hair cells / MGI
  • abnormal orientation of cochlear hair cell stereociliary bundles / MGI
  • abnormal inner hair cell stereociliary bundle morphology / MGI
  • abnormal cochlear hair cell inter-stereocilial links morphology / MGI
  • absent cochlear hair bundle ankle links / MGI
  • abnormal cochlear hair cell stereociliary bundle morphology / MGI
  • fused inner hair cell stereocilia / MGI

Literature references

  • A Myo7a mutation cosegregates with stereocilia defects and low-frequency hearing impairment.;Rhodes Charlotte R, Hertzano Ronna, Fuchs Helmut, Bell Rachel E, de Angelis Martin Hrabé, Steel Karen P, Avraham Karen B, ;2004;Mammalian genome : official journal of the International Mammalian Genome Society;15;686-97; 15389316

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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