STOCK Pax6tm1Pgr/Cnrm

Status

Available to order

EMMA IDEM:00998
International strain nameSTOCK Pax6tm1Pgr/Cnrm
Alternative nameRLA (Retinal enhancer-LAcZ)
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolPax6tm1Pgr,
Gene/Transgene symbolPax6

Information from provider

ProviderPeter Gruss
Provider affiliationMax Planck Inst. Biophysical Chemistry
Genetic informationAlpha-tau lacZ is driven by a Pax6 retinal enhancer: beta-galactosidase activity is found in retinal ganglion cells, their axons, superior colliculus and lateral geniculate nucleus.
Phenotypic informationAlteration of establishment of naso-temporal and dorsal characteristics of the optic vesicle.
References
  • Pax6 is required for establishing naso-temporal and dorsal characteristics of the optic vesicle.;Bäumer Nicole, Marquardt Till, Stoykova Anastassia, Ashery-Padan Ruth, Chowdhury Kamal, Gruss Peter, ;2002;Development (Cambridge, England);129;4535-45; 12223410

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • fused cornea and lens / MGI
  • abnormal iridocorneal angle / MGI
  • abnormal eye anterior chamber morphology / MGI
  • anterior iris synechia / MGI
  • anophthalmia / MGI
  • absent olfactory bulb / MGI
  • absent pancreatic alpha cells / MGI
  • disorganized pancreatic islets / MGI
  • neonatal lethality, complete penetrance / MGI
  • abnormal CNS synaptic transmission / MGI
  • abnormal spinal cord interneuron morphology / MGI
  • abnormal neuron physiology / MGI

Literature references

  • Pax6 is required for establishing naso-temporal and dorsal characteristics of the optic vesicle.;Bäumer Nicole, Marquardt Till, Stoykova Anastassia, Ashery-Padan Ruth, Chowdhury Kamal, Gruss Peter, ;2002;Development (Cambridge, England);129;4535-45; 12223410

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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