STOCK Srrm4^bv/WtsiH

Status	Available to order
EMMA ID	EM:01315
International strain name	STOCK Srrm4^bv/WtsiH
Alternative name	bv, Bronx Waltzer
Strain type	Spontaneous
Allele/Transgene symbol	Srrm4^bv,
Gene/Transgene symbol	Srrm4

Information from provider

Provider	Karen Steel
Provider affiliation	Wellcome Trust Sanger Institute
Genetic information	This is a spontaneous mutation affecting the sensory hair cells of the inner ear and leading to deafness and balance defects with circling and head bobbing.
Phenotypic information	This is a hearing impaired, recessive mutant that has a primary defect in the sensory cells of the organ of Corti of the inner ear. Homozygotes show circling and head bobbing and often do not show a Preyer reflex. Heterozygotes and wildtypes are not distinguishable from each other.
Breeding history	Originated on an unknown genetic background and maintained on same background within a closed colony for over 30 years.
References	Localization of the bronx waltzer (bv) deafness gene to mouse chromosome 5.;Bussoli T J, Kelly A, Steel K P, ;1997;Mammalian genome : official journal of the International Mammalian Genome Society;8;714-7; 9321462 The inner ear in Bronx waltzer mice.;Deol M S, ;1981;Acta oto-laryngologica;92;331-6; 7324900 Early development and degeneration of vestibular hair cells in bronx waltzer mutant mice.;Cheong Michael A, Steel Karen P, ;2002;Hearing research;164;179-89; 11950537 Characteristic findings of auditory brainstem response and otoacoustic emission in the Bronx waltzer mouse.;Inagaki Masumi, Kon Kaori, Suzuki Seiko, Kobayashi Naoko, Kaga Makiko, Nanba Eiji, ;2006;Brain & development;28;617-24; 16730938 Influence of neurotrophins on the synaptogenesis of inner hair cells in the deaf Bronx waltzer (bv) mouse organ of Corti in culture.;Sobkowicz Hanna M, August Benjamin K, Slapnick Susan M, ;2002;International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience;20;537-54; 12485622 Cochlear inner hair cells exist transiently in the fetal Bronx Waltzer (bv/bv) mouse.;Whitlon D S, Gabel C, Zhang X, ;1996;The Journal of comparative neurology;364;515-522; 8820880
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

MGI phenotypes (allele matching)

abnormal inner ear morphology / MGI
circling / MGI
abnormal pinna reflex / MGI
impaired balance / MGI
deafness / MGI
abnormal vestibular hair cell morphology / MGI
cochlear ganglion degeneration / MGI
abnormal pillar cell morphology / MGI
abnormal crista ampullaris morphology / MGI
absent pillar cells / MGI
decreased vestibular hair cell number / MGI
abnormal utricular macula morphology / MGI
utricular macular degeneration / MGI
abnormal cochlear inner hair cell morphology / MGI
decreased cochlear inner hair cell number / MGI
absent cochlear inner hair cells / MGI
cochlear inner hair cell degeneration / MGI
absent vestibular hair cell stereocilia / MGI
abnormal cochlear hair cell development / MGI
abnormal distortion product otoacoustic emission / MGI
head tossing / MGI
abnormal hearing electrophysiology / MGI
abnormal otoacoustic response / MGI
increased or absent threshold for auditory brainstem response / MGI

Literature references

Localization of the bronx waltzer (bv) deafness gene to mouse chromosome 5.;Bussoli T J, Kelly A, Steel K P, ;1997;Mammalian genome : official journal of the International Mammalian Genome Society;8;714-7; 9321462
The inner ear in Bronx waltzer mice.;Deol M S, ;1981;Acta oto-laryngologica;92;331-6; 7324900
Early development and degeneration of vestibular hair cells in bronx waltzer mutant mice.;Cheong Michael A, Steel Karen P, ;2002;Hearing research;164;179-89; 11950537
Characteristic findings of auditory brainstem response and otoacoustic emission in the Bronx waltzer mouse.;Inagaki Masumi, Kon Kaori, Suzuki Seiko, Kobayashi Naoko, Kaga Makiko, Nanba Eiji, ;2006;Brain & development;28;617-24; 16730938
Influence of neurotrophins on the synaptogenesis of inner hair cells in the deaf Bronx waltzer (bv) mouse organ of Corti in culture.;Sobkowicz Hanna M, August Benjamin K, Slapnick Susan M, ;2002;International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience;20;537-54; 12485622
Cochlear inner hair cells exist transiently in the fetal Bronx Waltzer (bv/bv) mouse.;Whitlon D S, Gabel C, Zhang X, ;1996;The Journal of comparative neurology;364;515-522; 8820880

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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STOCK Srrm4bv/WtsiH