B6.129-Braftm1Zim/Cnrm

Status

Available to order

EMMA IDEM:01389
International strain nameB6.129-Braftm1Zim/Cnrm
Alternative nameBraf Knock-out
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolBraftm1Zim,
Gene/Transgene symbolBraf

Information from provider

ProviderLeszek Wojnowski
Provider affiliationUniversity Mainz
Genetic informationSee Wojnowski et al., Endothelial apoptosis in Braf-deficient mice. Nature Genetics, 16: 293-297 (1997)
Phenotypic informationMid-gestational lethality, due to defective angiogenesis.
References
  • Endothelial apoptosis in Braf-deficient mice.;Wojnowski L, Zimmer A M, Beck T W, Hahn H, Bernal R, Rapp U R, Zimmer A, ;1997;Nature genetics;16;293-7; 9207797
  • Overlapping and specific functions of Braf and Craf-1 proto-oncogenes during mouse embryogenesis.;Wojnowski L, Stancato L F, Larner A C, Rapp U R, Zimmer A, ;2000;Mechanisms of development;91;97-104; 10704835

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • abnormal aorta morphology / MGI
  • abnormal head morphology / MGI
  • abnormal blood vessel morphology / MGI
  • poor circulation / MGI
  • abnormal apoptosis / MGI
  • hemorrhage / MGI
  • intraventricular hemorrhage / MGI
  • abnormal neuron morphology / MGI
  • abnormal vitelline vasculature morphology / MGI
  • abnormal cardinal vein morphology / MGI
  • hemopericardium / MGI
  • decreased heart rate / MGI
  • abnormal vascular endothelial cell morphology / MGI
  • increased vascular endothelial cell number / MGI
  • hematoma / MGI
  • decreased embryo weight / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • abnormal telencephalon development / MGI

Literature references

  • Endothelial apoptosis in Braf-deficient mice.;Wojnowski L, Zimmer A M, Beck T W, Hahn H, Bernal R, Rapp U R, Zimmer A, ;1997;Nature genetics;16;293-7; 9207797
  • Overlapping and specific functions of Braf and Craf-1 proto-oncogenes during mouse embryogenesis.;Wojnowski L, Stancato L F, Larner A C, Rapp U R, Zimmer A, ;2000;Mechanisms of development;91;97-104; 10704835

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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