MGI phenotypes (allele matching)
STOCK Igf2tm4Wrk/H
| Status | Available to order |
| EMMA ID | EM:01732 |
| International strain name | STOCK Igf2tm4Wrk/H |
| Alternative name | S1.2Neo |
| Strain type | Targeted Mutant Strains : Other targeted |
| Allele/Transgene symbol | Igf2tm4Wrk, |
| Gene/Transgene symbol | Igf2 |
Information from provider
| Provider | Dr Wolf Reik |
| Provider affiliation | The Babraham Institute, Babraham, Cambridge, CB2 4PB |
| Genetic information | Replacement vector containing a floxed neo-resistance gene, causing a small knock-out in a silencer region of the mouse Igf2 gene in a repressor protein binding site and leading to relative derepression of Igf2. |
| Phenotypic information | Intra-uterine growth restriction (paternal transmission). Loss of imprinting (maternal transmission). |
| References |
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Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Isolated hemihyperplasia / Orphanet_2128
- Silver-Russell syndrome due to a point mutation / Orphanet_397590
Literature references
- An upstream repressor element plays a role in Igf2 imprinting.;Eden S, Constancia M, Hashimshony T, Dean W, Goldstein B, Johnson A C, Keshet I, Reik W, Cedar H, ;2001;The EMBO journal;20;3518-25; 11432838