STOCK Prnptm1Cwe Tg(Eno2-Prnp)#Aag/Cnrm

Status

Available to order

EMMA IDEM:01837
International strain nameSTOCK Prnptm1Cwe Tg(Eno2-Prnp)#Aag/Cnrm
Alternative nameB6,129-TgN[NSE]Prnp ZH1/ZH1
Strain typeTransgenic Strains
Allele/Transgene symbolTg(Eno2-Prnp)#Aag,
Gene/Transgene symbolTg(Eno2-Prnp)#Aag

Information from provider

ProviderAdriano Aguzzi
Provider affiliationUniv.Hosp.Zurich/Inst.Neuropathology
Genetic informationPrnp expression under neuron-specific enolase 2 promoter (predominantly on neurons).
Breeding historyHeterozygous mice were crossed: F1. F1 transgene-positive NSE-Prnp mice were crossed with 129/Sv x C57BL/6. If all offspring mice were transgene-positive, the F1 generation was considerer to be homozygous: homozygous breeding.
References
  • Truncated prion protein and Doppel are myelinotoxic in the absence of oligodendrocytic PrPC.;Radovanovic Ivan, Braun Nathalie, Giger Olivier T, Mertz Kirsten, Miele Gino, Prinz Marco, Navarro Beatriz, Aguzzi Adriano, ;2005;The Journal of neuroscience : the official journal of the Society for Neuroscience;25;4879-88; 15888663

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • reduced long term potentiation / MGI
  • abnormal CNS synaptic transmission / MGI
  • abnormal inhibitory postsynaptic potential / MGI
  • abnormal inhibitory postsynaptic currents / MGI
  • behavior/neurological phenotype / MGI
  • decreased brain copper level / MGI
  • tremors / MGI
  • abnormal cerebellum morphology / MGI
  • decreased Purkinje cell number / MGI

Literature references

  • Truncated prion protein and Doppel are myelinotoxic in the absence of oligodendrocytic PrPC.;Radovanovic Ivan, Braun Nathalie, Giger Olivier T, Mertz Kirsten, Miele Gino, Prinz Marco, Navarro Beatriz, Aguzzi Adriano, ;2005;The Journal of neuroscience : the official journal of the Society for Neuroscience;25;4879-88; 15888663

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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