MGI phenotypes (allele matching)
STOCK Fasltm1.1Cgm/Ieg
| Status | Available to order |
| EMMA ID | EM:01885 |
| International strain name | STOCK Fasltm1.1Cgm/Ieg |
| Alternative name | FasL delta intra k.o./k.i. |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Fasltm1.1Cgm, |
| Gene/Transgene symbol | Fasl |
Information from provider
| Provider | Martin Zoernig |
| Provider affiliation | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus, University of Frankfurt |
| Genetic information | The wild-type Fas ligand (Fasl) allele was replaced with a deletion mutant which lacks the intracellular domain (i.e. aa 2-73). The targeting construct contained a tk-neo fusion cassette flanked by loxP sites for positive selection. This tk-neo cassette has been removed after breeding with CMV-cre recombinase deleter mice. |
| Phenotypic information | Homozygous mutants develop a lymphoaccumulation of T-cells in the periphery, similar to Fas ligand-deficient gld/gld mice (of a strain with a Fas ligand spontaneous mutant allele). In addition, mice probably develop autoimmune defects, again similar to gld/gld mice. Therefore, homozygous mice die within 4-6 months of age in the C57BL/6 background. |
| Breeding history | Backcrossed to C57BL/6 for 4 generations. |
| References | None available |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |