STOCK Tg(Lck-AVEN)1Zrng/Ieg
| Status | Available to order |
| EMMA ID | EM:01916 |
| International strain name | STOCK Tg(Lck-AVEN)1Zrng/Ieg |
| Alternative name | lck Aven |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Lck-AVEN)1Zrng, |
| Gene/Transgene symbol | Tg(Lck-AVEN)1Zrng |
Information from provider
| Provider | Martin Zoernig |
| Provider affiliation | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus, University of Frankfurt |
| Genetic information | Human AVEN cDNA was cloned and placed under control of the Lck promoter into the p1017 vector to achieve T cell-specific expression of the transgene. |
| Phenotypic information | The mice appear normal. |
| Breeding history | The transgenic mice were backcrossed for 4 generations to the C57BL/6 background. |
| References |
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Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Literature references
- Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1.;Chau B N, Cheng E H, Kerr D A, Hardwick J M, ;2000;Molecular cell;6;31-40; 10949025
- Involvement of p21ras distinguishes positive and negative selection in thymocytes.;Swan K A, Alberola-Ila J, Gross J A, Appleby M W, Forbush K A, Thomas J F, Perlmutter R M, ;1995;The EMBO journal;14;276-85; 7835338