MGI phenotypes (allele matching)
- increased pyruvate kinase activity / MGI
STOCK Pk27053/Ieg
| Status | Available to order |
| EMMA ID | EM:01947 |
| International strain name | STOCK Pk27053/Ieg |
| Alternative name | PK27506 |
| Strain type | Induced Mutant Strains : Chemically-induced |
| Allele/Transgene symbol | Pk27053, |
| Gene/Transgene symbol | Pk27053 |
Information from provider
| Provider | Walter Pretsch |
| Provider affiliation | Institute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH) |
| Genetic information | The mutation results in pyruvate kinase (PK) hyperactivity. It is suggested that the regulatory locus of PK is affected by this mutation. |
| Phenotypic information | The PK activity alteration was detected in blood and could also be found in the liver but not in muscle, kidney, heart, spleen, lung, or brain. Heterozygous mice have erythrocyte PK activity enhanced up to about 160% and homozygotes up to about 240%, compared to homozygous wild-type mice. The heterozygous and homozygous mutants are viable and fully fertile. |
| References | None available |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |