STOCK Mut1305/H
Status | Available to order |
EMMA ID | EM:01948 |
International strain name | STOCK Mut1305/H |
Alternative name | MUT/1305 |
Strain type | Induced Mutant Strains : Chemically-induced |
Allele/Transgene symbol | Mut1305, |
Gene/Transgene symbol | Mut1305 |
Information from provider
Provider | Bruce Cattanach |
Provider affiliation | MRC Harwell, Didcot, Oxon, OX11 0RD |
Genetic information | Original mutant was offspring of ENU treated (C3H/HeH x 101/H)F1 male mated to tester stock (PT) female. |
Phenotypic information | Small with white toes; sometimes with domed head. Affected heterozygotes are, on average, circa 30% smaller than normal littermates at birth, and about 20% smaller at weaning. Many have white toes; about 15% of affected mice have a noticeably domed head at weaning. Litter sizes are good, suggesting little pre/peri-natal loss of heterozygotes and thus penetrance of mutation phenotype is about 80%. Viability to weaning is about 70%. Homozygotes: data from openings strongly suggest that they die by early post implantation. |
Breeding history | Original background: (C3H/HeH x 101/H) x PT. Maintained background: C3H/HeH x 101/H. Breeding History Backcrossed to C3H/HeH x 101/H for several generations. |
References |
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Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI phenotypes (allele matching)
Literature references
- A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.;Nolan P M, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray I C, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson J A, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel K P, Voegeling S, Guenet J L, Nickols C, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher E M, Martin J, Rastan S, Brown S D, Hunter J, ;2000;Nature genetics;25;440-3; 10932191
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