B6;129-Apoetm1Bres Lgals3tm1Ftl/CljH

Status

Available to order

EMMA IDEM:02060
International strain nameB6;129-Apoetm1Bres Lgals3tm1Ftl/CljH
Alternative nameApoE/Gal3
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolLgals3tm1Ftl,
Gene/Transgene symbolLgals3

Information from provider

ProviderChristopher Jackson
Provider affiliationUniversity of Bristol
Genetic informationTargeted null mutation of the apolipoprotein E and galectin 3 genes.
Phenotypic informationNone.
References
  • Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells.;Plump A S, Smith J D, Hayek T, Aalto-Setälä K, Walsh A, Verstuyft J G, Rubin E M, Breslow J L, ;1992;Cell;71;343-53; 1423598
  • Targeted disruption of the galectin-3 gene results in attenuated peritoneal inflammatory responses.;Hsu D K, Yang R Y, Pan Z, Yu L, Salomon D R, Fung-Leung W P, Liu F T, ;2000;The American journal of pathology;156;1073-83; 10702423

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • abnormal digestive system physiology / MGI
  • increased circulating cholesterol level / MGI
  • abnormal circulating cholesterol level / MGI
  • xanthoma / MGI
  • atherosclerotic lesions / MGI
  • abnormal circulating LDL cholesterol level / MGI
  • abnormal cerebral cortex morphology / MGI
  • abnormal hippocampus morphology / MGI
  • abnormal neuron morphology / MGI
  • increased circulating VLDL cholesterol level / MGI
  • increased triglyceride level / MGI
  • increased susceptibility to atherosclerosis / MGI
  • decreased circulating HDL cholesterol level / MGI
  • increased circulating triglyceride level / MGI
  • brain inflammation / MGI
  • lung inflammation / MGI
  • abnormal dendritic cell physiology / MGI
  • abnormal CD8-positive, alpha-beta cytotoxic T cell morphology / MGI
  • increased IgG level / MGI
  • small intestinal inflammation / MGI
  • decreased macrophage cell number / MGI
  • abnormal response to infection / MGI
  • increased susceptibility to parasitic infection / MGI
  • abnormal interferon secretion / MGI
  • increased interleukin-12b secretion / MGI
  • abnormal liver morphology / MGI
  • abnormal hepatocyte morphology / MGI
  • focal hepatic necrosis / MGI
  • liver inflammation / MGI
  • hepatic steatosis / MGI
  • increased circulating alanine transaminase level / MGI
  • increased liver weight / MGI
  • increased hepatocellular carcinoma incidence / MGI
  • liver fibrosis / MGI
  • oxidative stress / MGI
  • increased liver triglyceride level / MGI
  • Mallory bodies / MGI
  • decreased monocyte cell number / MGI
  • abnormal leukocyte physiology / MGI
  • abnormal macrophage physiology / MGI
  • abnormal monocyte morphology / MGI
  • peritoneal inflammation / MGI
  • increased eosinophil cell number / MGI
  • decreased lymphocyte cell number / MGI
  • increased macrophage apoptosis / MGI

Literature references

  • Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells.;Plump A S, Smith J D, Hayek T, Aalto-Setälä K, Walsh A, Verstuyft J G, Rubin E M, Breslow J L, ;1992;Cell;71;343-53; 1423598
  • Targeted disruption of the galectin-3 gene results in attenuated peritoneal inflammatory responses.;Hsu D K, Yang R Y, Pan Z, Yu L, Salomon D R, Fung-Leung W P, Liu F T, ;2000;The American journal of pathology;156;1073-83; 10702423

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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