- abnormal digestive system physiology / MGI
- increased circulating cholesterol level / MGI
- abnormal circulating cholesterol level / MGI
- xanthoma / MGI
- atherosclerotic lesions / MGI
- abnormal circulating LDL cholesterol level / MGI
- abnormal cerebral cortex morphology / MGI
- abnormal hippocampus morphology / MGI
- abnormal neuron morphology / MGI
- increased circulating VLDL cholesterol level / MGI
- increased triglyceride level / MGI
- increased susceptibility to atherosclerosis / MGI
- decreased circulating HDL cholesterol level / MGI
- increased circulating triglyceride level / MGI
- brain inflammation / MGI
- lung inflammation / MGI
- abnormal dendritic cell physiology / MGI
- abnormal CD8-positive, alpha-beta cytotoxic T cell morphology / MGI
- increased IgG level / MGI
- small intestinal inflammation / MGI
- decreased macrophage cell number / MGI
- abnormal response to infection / MGI
- increased susceptibility to parasitic infection / MGI
- abnormal interferon secretion / MGI
- increased interleukin-12b secretion / MGI
- abnormal liver morphology / MGI
- abnormal hepatocyte morphology / MGI
- focal hepatic necrosis / MGI
- liver inflammation / MGI
- hepatic steatosis / MGI
- increased circulating alanine transaminase level / MGI
- increased liver weight / MGI
- increased hepatocellular carcinoma incidence / MGI
- liver fibrosis / MGI
- oxidative stress / MGI
- increased liver triglyceride level / MGI
- Mallory bodies / MGI
- decreased monocyte cell number / MGI
- abnormal leukocyte physiology / MGI
- abnormal macrophage physiology / MGI
- abnormal monocyte morphology / MGI
- peritoneal inflammation / MGI
- increased eosinophil cell number / MGI
- decreased lymphocyte cell number / MGI
- increased macrophage apoptosis / MGI
B6;129-Apoetm1Bres Lgals3tm1Ftl/CljH
Status | Available to order |
EMMA ID | EM:02060 |
International strain name | B6;129-Apoetm1Bres Lgals3tm1Ftl/CljH |
Alternative name | ApoE/Gal3 |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Lgals3tm1Ftl, |
Gene/Transgene symbol | Lgals3 |
Information from provider
Provider | Christopher Jackson |
Provider affiliation | University of Bristol |
Genetic information | Targeted null mutation of the apolipoprotein E and galectin 3 genes. |
Phenotypic information | None. |
References |
|
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Sea-blue histiocytosis / Orphanet_158029
- Lipoprotein glomerulopathy / Orphanet_329481
MGI phenotypes (allele matching)
Literature references
- Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells.;Plump A S, Smith J D, Hayek T, Aalto-Setälä K, Walsh A, Verstuyft J G, Rubin E M, Breslow J L, ;1992;Cell;71;343-53; 1423598
- Targeted disruption of the galectin-3 gene results in attenuated peritoneal inflammatory responses.;Hsu D K, Yang R Y, Pan Z, Yu L, Salomon D R, Fung-Leung W P, Liu F T, ;2000;The American journal of pathology;156;1073-83; 10702423
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