- abnormal digestive system physiology / MGI
- increased circulating cholesterol level / MGI
- abnormal circulating cholesterol level / MGI
- xanthoma / MGI
- atherosclerotic lesions / MGI
- abnormal circulating LDL cholesterol level / MGI
- abnormal cerebral cortex morphology / MGI
- abnormal hippocampus morphology / MGI
- abnormal neuron morphology / MGI
- increased circulating VLDL cholesterol level / MGI
- increased triglyceride level / MGI
- increased susceptibility to atherosclerosis / MGI
- decreased circulating HDL cholesterol level / MGI
- increased circulating triglyceride level / MGI
- decreased angiogenesis / MGI
- altered response to CNS ischemic injury / MGI
- abnormal microglial cell physiology / MGI
- intracerebral hemorrhage / MGI
- heart left ventricle hypertrophy / MGI
- reduced thrombolysis / MGI
- pulmonary interstitial fibrosis / MGI
- decreased susceptibility to induced choroidal neovascularization / MGI
- decreased susceptibility to induced retinal damage / MGI
- abnormal thrombosis / MGI
- growth/size/body region phenotype / MGI
- immune system phenotype / MGI
- reproductive system phenotype / MGI
- increased macrophage cell number / MGI
- decreased ventricle muscle contractility / MGI
- cardiac interstitial fibrosis / MGI
- decreased cerebral infarction size / MGI
- abnormal acute phase protein level / MGI
- mortality/aging / MGI
- pulmonary alveolar hemorrhage / MGI
- decreased retinal apoptosis / MGI
- decreased anxiety-related response / MGI
- decreased exploration in new environment / MGI
- abnormal cued conditioning behavior / MGI
- abnormal contextual conditioning behavior / MGI
- reduced long term potentiation / MGI
- increased circulating corticosterone level / MGI
- absent long term depression / MGI
- impaired synaptic plasticity / MGI
- decreased vertical activity / MGI
- abnormal active avoidance behavior / MGI
- abnormal motor learning / MGI
- chronic joint inflammation / MGI
- joint swelling / MGI
- arthritis / MGI
- muscle phenotype / MGI
- behavior/neurological phenotype / MGI
- decreased dopamine level / MGI
- abnormal cytokine level / MGI
- impaired conditioned place preference behavior / MGI
- impaired behavioral response to morphine / MGI
129(B6)-Apoetm1Bres Plattm1Mlg/CljH[cc]
Status | Available to order |
EMMA ID | EM:02063 |
International strain name | 129(B6)-Apoetm1Bres Plattm1Mlg/CljH[cc] |
Alternative name | ApoE/tPA |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Plattm1Mlg, |
Gene/Transgene symbol | Plat |
Information from provider
Provider | Christopher Jackson |
Provider affiliation | University of Bristol |
Genetic information | Targeted null mutation of the apolipoprotein E and tissue plasminogen activator (Plat, or tPA) genes. |
Phenotypic information | None. |
References |
|
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Sea-blue histiocytosis / Orphanet_158029
- Lipoprotein glomerulopathy / Orphanet_329481
- Lethal hydranencephaly-diaphragmatic hernia syndrome / Orphanet_480528
MGI phenotypes (allele matching)
Literature references
- Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells.;Plump A S, Smith J D, Hayek T, Aalto-Setälä K, Walsh A, Verstuyft J G, Rubin E M, Breslow J L, ;1992;Cell;71;343-53; 1423598
- Studies of mice lacking plasminogen activator gene function suggest that plasmin production prior to ovulation exceeds the amount needed for optimal ovulation efficiency.;Ny A, Nordström L, Carmeliet P, Ny T, ;1997;European journal of biochemistry;244;487-93; 9119016
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