- abnormal digestive system physiology / MGI
- increased circulating cholesterol level / MGI
- abnormal circulating cholesterol level / MGI
- xanthoma / MGI
- atherosclerotic lesions / MGI
- abnormal circulating LDL cholesterol level / MGI
- abnormal cerebral cortex morphology / MGI
- abnormal hippocampus morphology / MGI
- abnormal neuron morphology / MGI
- increased circulating VLDL cholesterol level / MGI
- increased triglyceride level / MGI
- increased susceptibility to atherosclerosis / MGI
- decreased circulating HDL cholesterol level / MGI
- increased circulating triglyceride level / MGI
- altered response to myocardial infarction / MGI
- abnormal cardiovascular system physiology / MGI
- premature death / MGI
- disorganized myocardium / MGI
- increased myocardial infarction size / MGI
- increased tumor growth/size / MGI
- renal/urinary system phenotype / MGI
- cardiovascular system phenotype / MGI
- immune system phenotype / MGI
- increased macrophage cell number / MGI
- ventricular fibrillation / MGI
- decreased susceptibility to endotoxin shock / MGI
- decreased sensitivity to induced morbidity/mortality / MGI
- abnormal mitochondrial ATP synthesis coupled electron transport / MGI
- decreased hematocrit / MGI
- hyperglycemia / MGI
- decreased circulating insulin level / MGI
- decreased erythrocyte cell number / MGI
- increased insulin sensitivity / MGI
- impaired glucose tolerance / MGI
- increased physiological sensitivity to xenobiotic / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- abnormal thymus morphology / MGI
- impaired macrophage phagocytosis / MGI
- homeostasis/metabolism phenotype / MGI
129.Cg-Tgm2tm1Gml Apoetm1Bres/CljH[cc]
Status | Available to order |
EMMA ID | EM:02064 |
International strain name | 129.Cg-Tgm2tm1Gml Apoetm1Bres/CljH[cc] |
Alternative name | ApoE/tTG |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Tgm2tm1Gml, |
Gene/Transgene symbol | Tgm2 |
Information from provider
Provider | Christopher Jackson |
Provider affiliation | University of Bristol |
Genetic information | Targeted null mutation of the apolipoprotein E and tissue transglutaminase genes. |
Phenotypic information | None. |
Breeding history | Outcrossed to 129 for more than 10 generations. Currently bred as a closed outbred colony. |
References |
|
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Sea-blue histiocytosis / Orphanet_158029
- Lipoprotein glomerulopathy / Orphanet_329481
MGI phenotypes (allele matching)
Literature references
- Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells.;Plump A S, Smith J D, Hayek T, Aalto-Setälä K, Walsh A, Verstuyft J G, Rubin E M, Breslow J L, ;1992;Cell;71;343-53; 1423598
- Gene disruption of tissue transglutaminase.;De Laurenzi V, Melino G, ;2001;Molecular and cellular biology;21;148-55; 11113189
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