129.Cg-Tgm2tm1Gml Apoetm1Bres/CljH[cc]

Status

Available to order

EMMA IDEM:02064
International strain name129.Cg-Tgm2tm1Gml Apoetm1Bres/CljH[cc]
Alternative nameApoE/tTG
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolTgm2tm1Gml,
Gene/Transgene symbolTgm2

Information from provider

ProviderChristopher Jackson
Provider affiliationUniversity of Bristol
Genetic informationTargeted null mutation of the apolipoprotein E and tissue transglutaminase genes.
Phenotypic informationNone.
Breeding historyOutcrossed to 129 for more than 10 generations. Currently bred as a closed outbred colony.
References
  • Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells.;Plump A S, Smith J D, Hayek T, Aalto-Setälä K, Walsh A, Verstuyft J G, Rubin E M, Breslow J L, ;1992;Cell;71;343-53; 1423598
  • Gene disruption of tissue transglutaminase.;De Laurenzi V, Melino G, ;2001;Molecular and cellular biology;21;148-55; 11113189

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • abnormal digestive system physiology / MGI
  • increased circulating cholesterol level / MGI
  • abnormal circulating cholesterol level / MGI
  • xanthoma / MGI
  • atherosclerotic lesions / MGI
  • abnormal circulating LDL cholesterol level / MGI
  • abnormal cerebral cortex morphology / MGI
  • abnormal hippocampus morphology / MGI
  • abnormal neuron morphology / MGI
  • increased circulating VLDL cholesterol level / MGI
  • increased triglyceride level / MGI
  • increased susceptibility to atherosclerosis / MGI
  • decreased circulating HDL cholesterol level / MGI
  • increased circulating triglyceride level / MGI
  • altered response to myocardial infarction / MGI
  • abnormal cardiovascular system physiology / MGI
  • premature death / MGI
  • disorganized myocardium / MGI
  • increased myocardial infarction size / MGI
  • increased tumor growth/size / MGI
  • renal/urinary system phenotype / MGI
  • cardiovascular system phenotype / MGI
  • immune system phenotype / MGI
  • increased macrophage cell number / MGI
  • ventricular fibrillation / MGI
  • decreased susceptibility to endotoxin shock / MGI
  • decreased sensitivity to induced morbidity/mortality / MGI
  • abnormal mitochondrial ATP synthesis coupled electron transport / MGI
  • decreased hematocrit / MGI
  • hyperglycemia / MGI
  • decreased circulating insulin level / MGI
  • decreased erythrocyte cell number / MGI
  • increased insulin sensitivity / MGI
  • impaired glucose tolerance / MGI
  • increased physiological sensitivity to xenobiotic / MGI
  • increased sensitivity to induced morbidity/mortality / MGI
  • abnormal thymus morphology / MGI
  • impaired macrophage phagocytosis / MGI
  • homeostasis/metabolism phenotype / MGI

Literature references

  • Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells.;Plump A S, Smith J D, Hayek T, Aalto-Setälä K, Walsh A, Verstuyft J G, Rubin E M, Breslow J L, ;1992;Cell;71;343-53; 1423598
  • Gene disruption of tissue transglutaminase.;De Laurenzi V, Melino G, ;2001;Molecular and cellular biology;21;148-55; 11113189

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

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