129(B6)-Apoetm1Bres Plgtm1Jld/CljH[cc]

Status

Available to order

EMMA IDEM:02065
International strain name129(B6)-Apoetm1Bres Plgtm1Jld/CljH[cc]
Alternative nameApoE/PLGN
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolPlgtm1Jld,
Gene/Transgene symbolPlg

Information from provider

ProviderChristopher Jackson
Provider affiliationUniversity of Bristol
Genetic informationTargeted null mutation of the apolipoprotein E and plasminogen genes.
Phenotypic informationRectal prolapse. Shortened life span in homozygotes.
References
  • Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells.;Plump A S, Smith J D, Hayek T, Aalto-Setälä K, Walsh A, Verstuyft J G, Rubin E M, Breslow J L, ;1992;Cell;71;343-53; 1423598
  • Biological effects of disruption of the tissue-type plasminogen activator, urokinase-type plasminogen activator, and plasminogen activator inhibitor-1 genes in mice.;Carmeliet P, Bouché A, De Clercq C, Janssen S, Pollefeyt S, Wyns S, Mulligan R C, Collen D, ;1995;Annals of the New York Academy of Sciences;748;367-81; discussion 381-2; 7695179

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • abnormal digestive system physiology / MGI
  • increased circulating cholesterol level / MGI
  • abnormal circulating cholesterol level / MGI
  • xanthoma / MGI
  • atherosclerotic lesions / MGI
  • abnormal circulating LDL cholesterol level / MGI
  • abnormal cerebral cortex morphology / MGI
  • abnormal hippocampus morphology / MGI
  • abnormal neuron morphology / MGI
  • increased circulating VLDL cholesterol level / MGI
  • increased triglyceride level / MGI
  • increased susceptibility to atherosclerosis / MGI
  • decreased circulating HDL cholesterol level / MGI
  • increased circulating triglyceride level / MGI
  • decreased angiogenesis / MGI
  • abnormal microglial cell physiology / MGI
  • decreased susceptibility to neuronal excitotoxicity / MGI
  • abnormal rectum morphology / MGI
  • decreased body weight / MGI
  • abnormal conjunctiva morphology / MGI
  • abnormal cornea morphology / MGI
  • eye inflammation / MGI
  • conjunctivitis / MGI
  • abnormal lactation / MGI
  • reduced female fertility / MGI
  • premature death / MGI
  • decreased tumor growth/size / MGI
  • increased hepatocyte proliferation / MGI
  • abnormal conjunctival epithelium morphology / MGI
  • abnormal corneal stroma morphology / MGI
  • corneal vascularization / MGI
  • abnormal corneal epithelium morphology / MGI
  • ectropion / MGI
  • eye hemorrhage / MGI
  • decreased sensitivity to induced morbidity/mortality / MGI
  • abnormal nervous system physiology / MGI
  • rectal prolapse / MGI
  • intestinal ulcer / MGI
  • abnormal liver morphology / MGI
  • abnormal vagina morphology / MGI
  • abnormal lung morphology / MGI
  • weight loss / MGI
  • impaired wound healing / MGI
  • abnormal larynx morphology / MGI
  • abnormal trachea morphology / MGI
  • colitis / MGI
  • duodenal ulcer / MGI
  • gastric ulcer / MGI
  • gastrointestinal ulcer / MGI
  • esophageal ulcer / MGI
  • perianal ulcer / MGI
  • abnormal thrombosis / MGI
  • cachexia / MGI
  • abnormal kidney thrombosis / MGI
  • abnormal stomach morphology / MGI
  • abnormal colon morphology / MGI
  • hepatic necrosis / MGI
  • proctitis / MGI
  • venoocclusion / MGI
  • abnormal body weight / MGI
  • cardiovascular system phenotype / MGI
  • abnormal mammary gland development / MGI
  • abnormal mammary gland growth during lactation / MGI
  • abnormal involution of the mammary gland / MGI
  • abnormal mammary gland connective tissue morphology / MGI
  • lactation failure / MGI

Literature references

  • Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells.;Plump A S, Smith J D, Hayek T, Aalto-Setälä K, Walsh A, Verstuyft J G, Rubin E M, Breslow J L, ;1992;Cell;71;343-53; 1423598
  • Biological effects of disruption of the tissue-type plasminogen activator, urokinase-type plasminogen activator, and plasminogen activator inhibitor-1 genes in mice.;Carmeliet P, Bouché A, De Clercq C, Janssen S, Pollefeyt S, Wyns S, Mulligan R C, Collen D, ;1995;Annals of the New York Academy of Sciences;748;367-81; discussion 381-2; 7695179

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).