- abnormal digestive system physiology / MGI
- increased circulating cholesterol level / MGI
- abnormal circulating cholesterol level / MGI
- xanthoma / MGI
- atherosclerotic lesions / MGI
- abnormal circulating LDL cholesterol level / MGI
- abnormal cerebral cortex morphology / MGI
- abnormal hippocampus morphology / MGI
- abnormal neuron morphology / MGI
- increased circulating VLDL cholesterol level / MGI
- increased triglyceride level / MGI
- increased susceptibility to atherosclerosis / MGI
- decreased circulating HDL cholesterol level / MGI
- increased circulating triglyceride level / MGI
- decreased angiogenesis / MGI
- abnormal microglial cell physiology / MGI
- decreased susceptibility to neuronal excitotoxicity / MGI
- abnormal rectum morphology / MGI
- decreased body weight / MGI
- abnormal conjunctiva morphology / MGI
- abnormal cornea morphology / MGI
- eye inflammation / MGI
- conjunctivitis / MGI
- abnormal lactation / MGI
- reduced female fertility / MGI
- premature death / MGI
- decreased tumor growth/size / MGI
- increased hepatocyte proliferation / MGI
- abnormal conjunctival epithelium morphology / MGI
- abnormal corneal stroma morphology / MGI
- corneal vascularization / MGI
- abnormal corneal epithelium morphology / MGI
- ectropion / MGI
- eye hemorrhage / MGI
- decreased sensitivity to induced morbidity/mortality / MGI
- abnormal nervous system physiology / MGI
- rectal prolapse / MGI
- intestinal ulcer / MGI
- abnormal liver morphology / MGI
- abnormal vagina morphology / MGI
- abnormal lung morphology / MGI
- weight loss / MGI
- impaired wound healing / MGI
- abnormal larynx morphology / MGI
- abnormal trachea morphology / MGI
- colitis / MGI
- duodenal ulcer / MGI
- gastric ulcer / MGI
- gastrointestinal ulcer / MGI
- esophageal ulcer / MGI
- perianal ulcer / MGI
- abnormal thrombosis / MGI
- cachexia / MGI
- abnormal kidney thrombosis / MGI
- abnormal stomach morphology / MGI
- abnormal colon morphology / MGI
- hepatic necrosis / MGI
- proctitis / MGI
- venoocclusion / MGI
- abnormal body weight / MGI
- cardiovascular system phenotype / MGI
- abnormal mammary gland development / MGI
- abnormal mammary gland growth during lactation / MGI
- abnormal involution of the mammary gland / MGI
- abnormal mammary gland connective tissue morphology / MGI
- lactation failure / MGI
129(B6)-Apoetm1Bres Plgtm1Jld/CljH[cc]
Status | Available to order |
EMMA ID | EM:02065 |
International strain name | 129(B6)-Apoetm1Bres Plgtm1Jld/CljH[cc] |
Alternative name | ApoE/PLGN |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Plgtm1Jld, |
Gene/Transgene symbol | Plg |
Information from provider
Provider | Christopher Jackson |
Provider affiliation | University of Bristol |
Genetic information | Targeted null mutation of the apolipoprotein E and plasminogen genes. |
Phenotypic information | Rectal prolapse. Shortened life span in homozygotes. |
References |
|
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Sea-blue histiocytosis / Orphanet_158029
- Lipoprotein glomerulopathy / Orphanet_329481
- PLG-related hereditary angioedema with normal C1Inh / Orphanet_537072
- Hypoplasminogenemia / Orphanet_722
MGI phenotypes (allele matching)
Literature references
- Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells.;Plump A S, Smith J D, Hayek T, Aalto-Setälä K, Walsh A, Verstuyft J G, Rubin E M, Breslow J L, ;1992;Cell;71;343-53; 1423598
- Biological effects of disruption of the tissue-type plasminogen activator, urokinase-type plasminogen activator, and plasminogen activator inhibitor-1 genes in mice.;Carmeliet P, Bouché A, De Clercq C, Janssen S, Pollefeyt S, Wyns S, Mulligan R C, Collen D, ;1995;Annals of the New York Academy of Sciences;748;367-81; discussion 381-2; 7695179
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