- abnormal digestive system physiology / MGI
- increased circulating cholesterol level / MGI
- abnormal circulating cholesterol level / MGI
- xanthoma / MGI
- atherosclerotic lesions / MGI
- abnormal circulating LDL cholesterol level / MGI
- abnormal cerebral cortex morphology / MGI
- abnormal hippocampus morphology / MGI
- abnormal neuron morphology / MGI
- increased circulating VLDL cholesterol level / MGI
- increased triglyceride level / MGI
- increased susceptibility to atherosclerosis / MGI
- decreased circulating HDL cholesterol level / MGI
- increased circulating triglyceride level / MGI
- heart inflammation / MGI
- increased susceptibility to bacterial infection / MGI
- cardiac fibrosis / MGI
- liver fibrosis / MGI
- liver/biliary system phenotype / MGI
- abnormal enzyme/coenzyme activity / MGI
- increased angiogenesis / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- decreased susceptibility to endotoxin shock / MGI
- decreased sensitivity to xenobiotic induced morbidity/mortality / MGI
- increased granulocyte number / MGI
- abnormal lung morphology / MGI
- abnormal body weight / MGI
- decreased body weight / MGI
- weight loss / MGI
- neoplasm / MGI
- abnormal blood circulation / MGI
- respiratory system inflammation / MGI
- abnormal acute inflammation / MGI
- enhanced wound healing / MGI
- glomerulonephritis / MGI
- increased urine protein level / MGI
- increased acute inflammation / MGI
- increased oxygen consumption / MGI
- decreased triglyceride level / MGI
- immune system phenotype / MGI
- hematopoietic system phenotype / MGI
- abnormal energy expenditure / MGI
- increased body temperature / MGI
- decreased angiogenesis / MGI
- abnormal epididymal fat pad morphology / MGI
- decreased circulating interleukin-6 level / MGI
- abnormal interleukin level / MGI
- decreased subcutaneous adipose tissue amount / MGI
- decreased liver triglyceride level / MGI
- glomerular crescent / MGI
- hyperglycemia / MGI
- abnormal kidney morphology / MGI
- decreased circulating cholesterol level / MGI
- abnormal renal glomerulus morphology / MGI
- homeostasis/metabolism phenotype / MGI
- increased blood urea nitrogen level / MGI
129(B6)-Serpine1tm1Mlg Apoetm1Bres/CljH[cc]
Status | Available to order |
EMMA ID | EM:02066 |
International strain name | 129(B6)-Serpine1tm1Mlg Apoetm1Bres/CljH[cc] |
Alternative name | ApoE/PAI-1 |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Serpine1tm1Mlg, |
Gene/Transgene symbol | Serpine1 |
Information from provider
Provider | Christopher Jackson |
Provider affiliation | University of Bristol |
Genetic information | Targeted null mutation of the apolipoprotein E and Serpine1 (formerly plasminogen activator inhibitor-1, PAI-1) genes. |
Phenotypic information | Shortened life span. |
Breeding history | Mice were congenic on a 129 background. |
References |
|
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Animals used for archiving | homozygous 129 |
Breeding at archiving centre | Males were archived at the time of arrival. No breeding was performed at the archiving centre. Males were understood to be homozygous congenic on a 129 background. |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Congenital plasminogen activator inhibitor type 1 deficiency / Orphanet_465
- Sea-blue histiocytosis / Orphanet_158029
- Lipoprotein glomerulopathy / Orphanet_329481
MGI phenotypes (allele matching)
Literature references
- Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells.;Plump A S, Smith J D, Hayek T, Aalto-Setälä K, Walsh A, Verstuyft J G, Rubin E M, Breslow J L, ;1992;Cell;71;343-53; 1423598
- Biological effects of disruption of the tissue-type plasminogen activator, urokinase-type plasminogen activator, and plasminogen activator inhibitor-1 genes in mice.;Carmeliet P, Bouché A, De Clercq C, Janssen S, Pollefeyt S, Wyns S, Mulligan R C, Collen D, ;1995;Annals of the New York Academy of Sciences;748;367-81; discussion 381-2; 7695179
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).