- abnormal enteric neuron morphology / MGI
- intestinal hypoperistalsis / MGI
- abnormal neurotransmitter secretion / MGI
- single kidney / MGI
- decreased renal glomerulus number / MGI
- absent kidney / MGI
- abnormal ureter morphology / MGI
- absent superior cervical ganglion / MGI
- abnormal stellate ganglion morphology / MGI
- absent enteric neurons / MGI
- abnormal lung development / MGI
- abnormal kidney morphology / MGI
- dilated renal tubules / MGI
- small kidney / MGI
- dilated renal glomerular capsule / MGI
- abnormal ureter development / MGI
- abnormal cardiac ganglion morphology / MGI
- absent ureter / MGI
- abnormal kidney collecting duct morphology / MGI
- cardiovascular system phenotype / MGI
- abnormal parasympathetic postganglionic fiber morphology / MGI
- abnormal mesonephros morphology / MGI
- abnormal branching involved in ureteric bud morphogenesis / MGI
- abnormal ureteric bud elongation / MGI
- abnormal ureteric bud invasion / MGI
- abnormal metanephric mesenchyme morphology / MGI
- abnormal kidney mesenchyme morphology / MGI
- neonatal lethality, complete penetrance / MGI
- increased metanephric mesenchyme apoptosis / MGI
- absent nephrogenic zone / MGI
- blind ureter / MGI
- oligohydramnios / MGI
- abnormal enteric neural crest cell migration / MGI
- endocrine/exocrine gland phenotype / MGI
- abnormal enteric nervous system morphology / MGI
- abnormal enteric ganglia morphology / MGI
- neoplasm / MGI
- reproductive system phenotype / MGI
- aganglionic megacolon / MGI
- renal hypoplasia / MGI
STOCK Rettm1Cos/Kctt
Status | Available to order |
EMMA ID | EM:02081 |
International strain name | STOCK Rettm1Cos/Kctt |
Alternative name | Ret KO |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Rettm1Cos, |
Gene/Transgene symbol | Ret |
Information from provider
Provider | Christel Baudet |
Provider affiliation | Universite Bordeaux 2 |
Genetic information | Ubiquitous deletion of exons 12 and 13 after crossing the conditional Ret floxed allele with a cre-deleter strain, thereby generating a 'kinase dead receptor'. An FRT site is left in the genome after the excision of the FRT flanked neomycin cassette by flp recombinase. |
Phenotypic information | Homozygous mice die at birth of kidney agenesis. Heterozygous mice are viable and fertile. |
References |
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Information from EMMA
Archiving centre | Karolinska Institutet, Stockholm, Sweden |
Disease and phenotype information
MGI allele-associated human disease models
Orphanet associated rare diseases, based on orthologous gene matching
- Renal agenesis, bilateral / Orphanet_1848
- Multiple endocrine neoplasia type 2B / Orphanet_247709
- Familial medullary thyroid carcinoma / Orphanet_99361
- Renal agenesis, unilateral / Orphanet_93100
- Haddad syndrome / Orphanet_99803
- Multiple endocrine neoplasia type 2A / Orphanet_247698
- Hirschsprung disease / Orphanet_388
MGI phenotypes (allele matching)
Literature references
- Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret.;Schuchardt A, D'Agati V, Larsson-Blomberg L, Costantini F, Pachnis V, ;1994;Nature;367;380-3; 8114940
- Renal agenesis and hypodysplasia in ret-k- mutant mice result from defects in ureteric bud development.;Schuchardt A, D'Agati V, Pachnis V, Costantini F, ;1996;Development (Cambridge, England);122;1919-29; 8674430
- Retrograde signaling onto Ret during motor nerve terminal maturation.;Baudet Christel, Pozas Ester, Adameyko Igor, Andersson Elisabet, Ericson Johan, Ernfors Patrik, ;2008;The Journal of neuroscience : the official journal of the Society for Neuroscience;28;963-75; 18216204
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