CByIco.129S7-Ifngtm1Ts/Cnrm

Status

Available to order

EMMA IDEM:02106
International strain nameCByIco.129S7-Ifngtm1Ts/Cnrm
Alternative nameBALB/cByJIco IFNg-/-
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolIfngtm1Ts,
Gene/Transgene symbolIfng

Information from provider

ProviderUrsula Günthert
Provider affiliationInstitut für Pathologie, University of Basel
Genetic informationInsertion of a neomycin gene into exon 2 of Ifng (interferon gamma) gene, which introduced a termination codon after the first 30 amino acids of the mature protein.
Phenotypic informationIfng (interferon gamma) -/-: reduced macrophage function with impaired production of antimicrobial products; reduced MHCII expression and abnormal natural killer cell development.
Breeding historyBackcrossed for 10 generations onto BALB/cByJIco.
References
  • Multiple defects of immune cell function in mice with disrupted interferon-gamma genes.;Dalton D K, Pitts-Meek S, Keshav S, Figari I S, Bradley A, Stewart T A, ;1993;Science (New York, N.Y.);259;1739-42; 8456300

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI allele-associated human disease models

MGI phenotypes (allele matching)
  • increased leukocyte cell number / MGI
  • increased monocyte cell number / MGI
  • extramedullary hematopoiesis / MGI
  • increased granulocyte number / MGI
  • abnormal spleen morphology / MGI
  • enlarged spleen / MGI
  • abnormal response to new environment / MGI
  • abnormal humoral immune response / MGI
  • stomach inflammation / MGI
  • abnormal spleen red pulp morphology / MGI
  • abnormal spleen white pulp morphology / MGI
  • abnormal dendritic cell physiology / MGI
  • increased susceptibility to bacterial infection / MGI
  • abnormal dendritic cell antigen presentation / MGI
  • abnormal immunoglobulin level / MGI
  • abnormal type IV hypersensitivity reaction / MGI
  • glomerulonephritis / MGI
  • decreased vertical activity / MGI
  • albuminuria / MGI
  • abnormal cytokine secretion / MGI
  • abnormal redox activity / MGI
  • increased fear-related response / MGI
  • abnormal nitric oxide homeostasis / MGI
  • decreased length of allograft survival / MGI
  • abnormal immune tolerance / MGI
  • increased susceptibility to parasitic infection / MGI
  • abnormal response to injury / MGI
  • decreased susceptibility to injury / MGI
  • abnormal Langerhans cell physiology / MGI
  • immune system phenotype / MGI
  • increased susceptibility to type IV hypersensitivity reaction / MGI
  • increased NK T cell number / MGI
  • enlarged mesenteric lymph nodes / MGI
  • decreased interferon-gamma secretion / MGI
  • increased circulating interleukin-6 level / MGI
  • decreased interleukin-10 secretion / MGI
  • increased interleukin-12 secretion / MGI
  • increased interleukin-4 secretion / MGI
  • pale spleen / MGI
  • skeletal muscle fibrosis / MGI
  • abnormal urine homeostasis / MGI
  • increased sensitivity to xenobiotic induced morbidity/mortality / MGI
  • increased susceptibility to bacterial infection induced morbidity/mortality / MGI
  • abnormal circulating cytokine level / MGI
  • abnormal dendritic cell chemotaxis / MGI
  • increased susceptibility to parasitic infection induced morbidity/mortality / MGI
  • abnormal macrophage chemotaxis / MGI
  • impaired skeletal muscle regeneration / MGI
  • abnormal inflammatory response / MGI
  • decreased litter size / MGI
  • abnormal adaptive immunity / MGI
  • abnormal macrophage physiology / MGI
  • abnormal maternal decidual layer morphology / MGI
  • decreased susceptibility to parasitic infection / MGI
  • abnormal cytotoxic T cell physiology / MGI
  • abnormal uterine NK cell morphology / MGI
  • abnormal uterine NK cell physiology / MGI
  • increased uterine NK cell number / MGI
  • decreased tumor latency / MGI
  • altered tumor pathology / MGI
  • abnormal NK cell physiology / MGI
  • abnormal pancreatic beta cell physiology / MGI
  • decreased susceptibility to autoimmune diabetes / MGI
  • increased T cell derived lymphoma incidence / MGI
  • increased sarcoma incidence / MGI
  • premature death / MGI
  • increased susceptibility to viral infection / MGI
  • abnormal B cell physiology / MGI
  • increased IgE level / MGI
  • abnormal response to infection / MGI
  • abnormal response to transplant / MGI
  • increased CD8-positive, alpha-beta T cell number / MGI
  • decreased IgG2a level / MGI
  • decreased IgG3 level / MGI
  • increased IgG1 level / MGI
  • increased interleukin-10 secretion / MGI
  • increased interleukin-2 secretion / MGI
  • increased interleukin-5 secretion / MGI
  • abnormal lymph node cell ratio / MGI
  • increased susceptibility to viral infection induced morbidity/mortality / MGI
  • increased lymphoma incidence / MGI
  • neoplasm / MGI
  • increased lung adenocarcinoma incidence / MGI
  • increased susceptibility to experimental autoimmune encephalomyelitis / MGI
  • increased tumor latency / MGI
  • altered susceptibility to autoimmune disorder / MGI
  • increased metastatic potential / MGI
  • decreased tumor incidence / MGI
  • abnormal MHC II cell surface expression on macrophages / MGI
  • abnormal skin physiology / MGI
  • increased splenocyte proliferation / MGI
  • decreased susceptibility to parasitic infection induced morbidity/mortality / MGI
  • alveolar process atrophy / MGI
  • impaired natural killer cell mediated cytotoxicity / MGI
  • corneal vascularization / MGI
  • decreased susceptibility to type IV hypersensitivity reaction / MGI
  • increased interleukin-17 secretion / MGI
  • abnormal cytokine level / MGI
  • altered susceptibility to infection / MGI
  • decreased inflammatory response / MGI
  • increased airway responsiveness / MGI
  • decreased airway responsiveness / MGI
  • decreased IgE level / MGI
  • decreased IgM level / MGI
  • decreased IgA level / MGI
  • decreased immunoglobulin level / MGI
  • decreased autoantibody level / MGI
  • decreased anti-nuclear antigen antibody level / MGI
  • decreased anti-double stranded DNA antibody level / MGI
  • decreased susceptibility to autoimmune disorder / MGI
  • decreased IgG2b level / MGI
  • decreased IgG level / MGI
  • decreased physiological sensitivity to xenobiotic / MGI

Literature references

  • Multiple defects of immune cell function in mice with disrupted interferon-gamma genes.;Dalton D K, Pitts-Meek S, Keshav S, Figari I S, Bradley A, Stewart T A, ;1993;Science (New York, N.Y.);259;1739-42; 8456300

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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