STOCK Igh-8tm2(Ighg1)Aak/Orl
Status | Available to order |
EMMA ID | EM:02110 |
International strain name | STOCK Igh-8tm2(Ighg1)Aak/Orl |
Alternative name | Ig1/Ig3 |
Strain type | Targeted Mutant Strains : Knock-in |
Allele/Transgene symbol | Igh-8tm2(Ighg1)Aak, |
Gene/Transgene symbol | Igh-8 |
Information from provider
Provider | Ahmed Amine Khamlichi |
Provider affiliation | CNRS UMR 6101 |
Genetic information | The targeting construct is from 129 DNA. The Ig3 germline promoter was replaced by Ig1 germline promoter leading to a duplication of Ig1 promoter within the IgH locus. |
Phenotypic information | Inhibition of class switching to IgG3 despite abundant germline transcription. |
Breeding history | Bred with C57BL/6 for several generations. |
References |
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Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
MGI phenotypes (allele matching)
Literature references
- Replacement of Igamma3 germ-line promoter by Igamma1 inhibits class-switch recombination to IgG3.;Oruc Zeliha, Boumédiène Ahmed, Le Bert Marc, Khamlichi Ahmed Amine, ;2007;Proceedings of the National Academy of Sciences of the United States of America;104;20484-9; 18077389
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