STOCK Igh-8tm2(Ighg1)Aak/Orl

Status

Available to order

EMMA IDEM:02110
International strain nameSTOCK Igh-8tm2(Ighg1)Aak/Orl
Alternative nameIg1/Ig3
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolIgh-8tm2(Ighg1)Aak,
Gene/Transgene symbolIgh-8

Information from provider

ProviderAhmed Amine Khamlichi
Provider affiliationCNRS UMR 6101
Genetic informationThe targeting construct is from 129 DNA. The Ig3 germline promoter was replaced by Ig1 germline promoter leading to a duplication of Ig1 promoter within the IgH locus.
Phenotypic informationInhibition of class switching to IgG3 despite abundant germline transcription.
Breeding historyBred with C57BL/6 for several generations.
References
  • Replacement of Igamma3 germ-line promoter by Igamma1 inhibits class-switch recombination to IgG3.;Oruc Zeliha, Boumédiène Ahmed, Le Bert Marc, Khamlichi Ahmed Amine, ;2007;Proceedings of the National Academy of Sciences of the United States of America;104;20484-9; 18077389

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

MGI phenotypes (allele matching)
  • abnormal class switch recombination / MGI
  • decreased IgG3 level / MGI

Literature references

  • Replacement of Igamma3 germ-line promoter by Igamma1 inhibits class-switch recombination to IgG3.;Oruc Zeliha, Boumédiène Ahmed, Le Bert Marc, Khamlichi Ahmed Amine, ;2007;Proceedings of the National Academy of Sciences of the United States of America;104;20484-9; 18077389

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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