STOCK Lig4tiny/ApbH

Status

Available to order

EMMA IDEM:02183
International strain nameSTOCK Lig4tiny/ApbH
Alternative nameTiny, C57BL/6Apb-Lig4/Apb
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolLig4tiny,
Gene/Transgene symbolLig4

Information from provider

ProviderChris Goodnow
Provider affiliationThe Australian National University
Genetic informationThis mutant line is small in size, has no CD8 cells or B cells. This strain was identified during systematically screening of the mouse genome for autoimmune regulators. The strain is similar to human severe combined immunodeficiency (SCID). This strain has a phenotype which is less severe than the published null mutations.
Phenotypic informationThis mutant line is small in size and has no CD8 cells or B cells.
References
  • DNA repair is limiting for haematopoietic stem cells during ageing.;Nijnik Anastasia, Woodbine Lisa, Marchetti Caterina, Dawson Sara, Lambe Teresa, Liu Cong, Rodrigues Neil P, Crockford Tanya L, Cabuy Erik, Vindigni Alessandro, Enver Tariq, Bell John I, Slijepcevic Predrag, Goodnow Christopher C, Jeggo Penelope A, Cornall Richard J, ;2007;Nature;447;686-90; 17554302

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

MGI allele-associated human disease models

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • decreased bone marrow cell number / MGI
  • absent CD8-positive, alpha-beta T cells / MGI
  • decreased body size / MGI
  • postnatal growth retardation / MGI
  • abnormal proerythroblast morphology / MGI
  • decreased hematopoietic stem cell number / MGI
  • decreased lymphocyte cell number / MGI
  • decreased B cell number / MGI
  • abnormal DNA repair / MGI
  • prenatal lethality, incomplete penetrance / MGI
  • decreased fibroblast proliferation / MGI

Literature references

  • DNA repair is limiting for haematopoietic stem cells during ageing.;Nijnik Anastasia, Woodbine Lisa, Marchetti Caterina, Dawson Sara, Lambe Teresa, Liu Cong, Rodrigues Neil P, Crockford Tanya L, Cabuy Erik, Vindigni Alessandro, Enver Tariq, Bell John I, Slijepcevic Predrag, Goodnow Christopher C, Jeggo Penelope A, Cornall Richard J, ;2007;Nature;447;686-90; 17554302

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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