STOCK Tg(MSR1)3Winth/Cnrm

Status	Available to order
EMMA ID	EM:02188
International strain name	STOCK Tg(MSR1)3Winth/Cnrm
Alternative name	MSR1
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(MSR1)3Winth,
Gene/Transgene symbol	Tg(MSR1)3Winth

Information from provider

Provider	Menno de Winther
Provider affiliation	Institute for Genetics, University of Cologne
Genetic information	Transgenic mice were generated using a 180-kb Yeast Artificial Chromosome (YAC), carrying the complete human macrophage scavenger receptor class A (MSR1 or SR-A) gene including promoter region. This leads to 2-3 fold increased MSR1 activity in macrophages.
Phenotypic information	Increased scavenger receptor activity
References	Macrophage specific overexpression of the human macrophage scavenger receptor in transgenic mice, using a 180-kb yeast artificial chromosome, leads to enhanced foam cell formation of isolated peritoneal macrophages.;de Winther M P, van Dijk K W, van Vlijmen B J, Gijbels M J, Heus J J, Wijers E R, van den Bos A C, Breuer M, Frants R R, Havekes L M, Hofker M H, ;1999;Atherosclerosis;147;339-47; 10559520 Effect of human scavenger receptor class A overexpression in bone marrow-derived cells on lipoprotein metabolism and atherosclerosis in low density lipoprotein receptor knockout mice.;Herijgers N, de Winther M P, Van Eck M, Havekes L M, Hofker M H, Hoogerbrugge P M, Van Berkel T J, ;2000;Journal of lipid research;41;1402-9; 10974047 Effect of human scavenger receptor class A overexpression in bone marrow-derived cells on cholesterol levels and atherosclerosis in ApoE-deficient mice.;Van Eck M, De Winther M P, Herijgers N, Havekes L M, Hofker M H, Groot P H, Van Berkel T J, ;2000;Arteriosclerosis, thrombosis, and vascular biology;20;2600-6; 11116059

Information from EMMA

Archiving centre	CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Literature references

Macrophage specific overexpression of the human macrophage scavenger receptor in transgenic mice, using a 180-kb yeast artificial chromosome, leads to enhanced foam cell formation of isolated peritoneal macrophages.;de Winther M P, van Dijk K W, van Vlijmen B J, Gijbels M J, Heus J J, Wijers E R, van den Bos A C, Breuer M, Frants R R, Havekes L M, Hofker M H, ;1999;Atherosclerosis;147;339-47; 10559520
Effect of human scavenger receptor class A overexpression in bone marrow-derived cells on lipoprotein metabolism and atherosclerosis in low density lipoprotein receptor knockout mice.;Herijgers N, de Winther M P, Van Eck M, Havekes L M, Hofker M H, Hoogerbrugge P M, Van Berkel T J, ;2000;Journal of lipid research;41;1402-9; 10974047
Effect of human scavenger receptor class A overexpression in bone marrow-derived cells on cholesterol levels and atherosclerosis in ApoE-deficient mice.;Van Eck M, De Winther M P, Herijgers N, Havekes L M, Hofker M H, Groot P H, Van Berkel T J, ;2000;Arteriosclerosis, thrombosis, and vascular biology;20;2600-6; 11116059

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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