- embryonic lethality / MGI
STOCK Smg6Tg(SMN1*delta5)1Pks/H
Status | Available to order |
EMMA ID | EM:02416 |
International strain name | STOCK Smg6Tg(SMN1*delta5)1Pks/H |
Alternative name | SMNDelta5 |
Strain type | Transgenic Strains |
Allele/Transgene symbol | Smg6Tg(SMN1*delta5)1Pks, |
Gene/Transgene symbol | Smg6 |
Information from provider
Provider | Nicholas Parkinson |
Provider affiliation | University of Oxford |
Genetic information | This line overexpresses a cDNA splice isoform of human SMN that is missing exon 5, SMNDelta5. The promoter is a 750bp fragment of the human SMN1 promoter. The transgene is stably integrated as a single copy into Intron 13 of the Smg6 locus on Chromosome 11. This transgene is maintained as a heterozygote on an FVB/N background and expresses in all tissues tested. Heterozygotes have no deleterious phenotype on a wildtype background but homozygotes are embryonic lethal. |
Phenotypic information | None |
References | None available |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Animals used for archiving | heterozygous FVB/N |
Breeding at archiving centre | Males were archived by sperm freezing on arrival. No breeding was performed at the archiving centre. |
Disease and phenotype information
MGI phenotypes (allele matching)
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