STOCK Tg(Prnp-SMN)92Ahmb/H
| Status | Available to order |
| EMMA ID | EM:02501 |
| International strain name | STOCK Tg(Prnp-SMN)92Ahmb/H |
| Alternative name | PrP : fl-SMN |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Prnp-SMN)92Ahmb, |
| Gene/Transgene symbol | Tg(Prnp-SMN)92Ahmb |
Information from provider
| Provider | Nicholas Parkinson |
| Provider affiliation | University of Oxford |
| Additional owner | Prof. Arthur Burghes, The Ohio State University, Columbus OH, USA |
| Genetic information | Full length human SMN transgene behind PrP promoter, as developed by Arthur Burghes. |
| Phenotypic information | These mice are aphenotypic. |
| Breeding history | This transgene was originally maintained on the SMN2-low background (see paper). We have outcrossed these animals to FVB to segregate the PrP:Fl-SMN transgene away from other transgenes and knockout alleles. These animals have been maintained on an FVB/N background for two generations. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | heterozygous FVB |
| Breeding at archiving centre | None. Males were archived at the time of arrival at the archiving centre. |
Literature references
- Neuronal SMN expression corrects spinal muscular atrophy in severe SMA mice while muscle-specific SMN expression has no phenotypic effect.;Gavrilina Tatiana O, McGovern Vicki L, Workman Eileen, Crawford Thomas O, Gogliotti Rocky G, DiDonato Christine J, Monani Umrao R, Morris Glenn E, Burghes Arthur H M, ;2008;Human molecular genetics;17;1063-75; 18178576