STOCK Smad9tm1Rob/H
| Status | Available to order |
| EMMA ID | EM:02507 |
| International strain name | STOCK Smad9tm1Rob/H |
| Alternative name | Smad8 LacZ |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Smad9tm1Rob, |
| Gene/Transgene symbol | Smad9 |
Information from provider
| Provider | Elizabeth Robertson |
| Provider affiliation | Sir William Dunn School of Pathology, University of Oxford |
| Genetic information | Reporter allele of Smad8 via inframe knock-in of a LacZ coding sequence into the Smad 8 locus. Expression of beta-galactosidase reflects the transcriptional activity of the endogenous Smad8 locus. Tissue sites of robust LacZ expression include the bones of the skeleton, gut endoderm and selected neural tissues. |
| Phenotypic information | No overt phenotype. |
| Breeding history | Outcrossed onto CD1. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- Dose-dependent Smad1, Smad5 and Smad8 signaling in the early mouse embryo.;Arnold Sebastian J, Maretto Silvia, Islam Ayesha, Bikoff Elizabeth K, Robertson Elizabeth J, ;2006;Developmental biology;296;104-18; 16765933