STOCK Smad9tm1Rob/H
Status | Available to order |
EMMA ID | EM:02507 |
International strain name | STOCK Smad9tm1Rob/H |
Alternative name | Smad8 LacZ |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Smad9tm1Rob, |
Gene/Transgene symbol | Smad9 |
Information from provider
Provider | Elizabeth Robertson |
Provider affiliation | Sir William Dunn School of Pathology, University of Oxford |
Genetic information | Reporter allele of Smad8 via inframe knock-in of a LacZ coding sequence into the Smad 8 locus. Expression of beta-galactosidase reflects the transcriptional activity of the endogenous Smad8 locus. Tissue sites of robust LacZ expression include the bones of the skeleton, gut endoderm and selected neural tissues. |
Phenotypic information | No overt phenotype. |
Breeding history | Outcrossed onto CD1. |
References |
|
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | not known |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- Dose-dependent Smad1, Smad5 and Smad8 signaling in the early mouse embryo.;Arnold Sebastian J, Maretto Silvia, Islam Ayesha, Bikoff Elizabeth K, Robertson Elizabeth J, ;2006;Developmental biology;296;104-18; 16765933
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).