STOCK Smad2tm4(SMADH3)Rob/H
Status | Available to order |
EMMA ID | EM:02508 |
International strain name | STOCK Smad2tm4(SMADH3)Rob/H |
Alternative name | Smad2 T3 |
Strain type | Targeted Mutant Strains : Knock-in |
Allele/Transgene symbol | Smad2tm4(SMADH3)Rob, |
Gene/Transgene symbol | Smad2 |
Information from provider
Provider | Elizabeth Robertson |
Provider affiliation | Sir William Dunn School of Pathology, University of Oxford |
Genetic information | Knock-in allele of human FLAG tagged Smad3 cDNA into exon1 of Smad2 locus. Resulting mice exclusively express Smad3 and do not express any Smad2 endogenously. |
Phenotypic information | Approximately 50% of homozygotes are embryonic lethal at 15.5 dpc. The remainder are viable as adults. |
Breeding history | Backcrossed to 129/SvEv. |
References |
|
Homozygous fertile | not known |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | not known |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Familial thoracic aortic aneurysm and aortic dissection / Orphanet_91387
MGI phenotypes (allele matching)
Literature references
- Mice exclusively expressing the short isoform of Smad2 develop normally and are viable and fertile.;Dunn N Ray, Koonce Chad H, Anderson Dorian C, Islam Ayesha, Bikoff Elizabeth K, Robertson Elizabeth J, ;2005;Genes & development;19;152-63; 15630024
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