STOCK Smad2tm4(SMADH3)Rob/H

Status

Available to order

EMMA IDEM:02508
International strain nameSTOCK Smad2tm4(SMADH3)Rob/H
Alternative nameSmad2 T3
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolSmad2tm4(SMADH3)Rob,
Gene/Transgene symbolSmad2

Information from provider

ProviderElizabeth Robertson
Provider affiliationSir William Dunn School of Pathology, University of Oxford
Genetic informationKnock-in allele of human FLAG tagged Smad3 cDNA into exon1 of Smad2 locus. Resulting mice exclusively express Smad3 and do not express any Smad2 endogenously.
Phenotypic informationApproximately 50% of homozygotes are embryonic lethal at 15.5 dpc. The remainder are viable as adults.
Breeding historyBackcrossed to 129/SvEv.
References
  • Mice exclusively expressing the short isoform of Smad2 develop normally and are viable and fertile.;Dunn N Ray, Koonce Chad H, Anderson Dorian C, Islam Ayesha, Bikoff Elizabeth K, Robertson Elizabeth J, ;2005;Genes & development;19;152-63; 15630024
Homozygous fertilenot known
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisednot known

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • microcephaly / MGI
  • exencephaly / MGI
  • abnormal forebrain development / MGI
  • holoprosencephaly / MGI
  • abnormal hindbrain development / MGI
  • neonatal lethality, incomplete penetrance / MGI
  • prenatal lethality, incomplete penetrance / MGI

Literature references

  • Mice exclusively expressing the short isoform of Smad2 develop normally and are viable and fertile.;Dunn N Ray, Koonce Chad H, Anderson Dorian C, Islam Ayesha, Bikoff Elizabeth K, Robertson Elizabeth J, ;2005;Genes & development;19;152-63; 15630024

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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