STOCK Smad2tm3Rob/H
| Status | Available to order |
| EMMA ID | EM:02509 |
| International strain name | STOCK Smad2tm3Rob/H |
| Alternative name | Smad2 D2 |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Smad2tm3Rob, |
| Gene/Transgene symbol | Smad2 |
Information from provider
| Provider | Elizabeth Robertson |
| Provider affiliation | Sir William Dunn School of Pathology, University of Oxford |
| Genetic information | Knock-out allele of human Smad2 in which the alternatively spliced exon (E3) has been removed from the Smad2 locus. Resulting mice express wild-type levels of the short isoform of Smad2. Animals are homozygous viable. |
| Phenotypic information | No overt phenotype. |
| Breeding history | Backcrossed to 129/SvEv. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Familial thoracic aortic aneurysm and aortic dissection / Orphanet_91387
Literature references
- Mice exclusively expressing the short isoform of Smad2 develop normally and are viable and fertile.;Dunn N Ray, Koonce Chad H, Anderson Dorian C, Islam Ayesha, Bikoff Elizabeth K, Robertson Elizabeth J, ;2005;Genes & development;19;152-63; 15630024