STOCK Smad2tm5(SMAD2)Rob/H
Status | Available to order |
EMMA ID | EM:02512 |
International strain name | STOCK Smad2tm5(SMAD2)Rob/H |
Alternative name | Smad2 FL |
Strain type | Targeted Mutant Strains : Knock-in |
Allele/Transgene symbol | Smad2tm5(SMAD2)Rob, |
Gene/Transgene symbol | Smad2 |
Information from provider
Provider | Elizabeth Robertson |
Provider affiliation | Sir William Dunn School of Pathology, University of Oxford |
Genetic information | Knock-in allele of Smad2 of a FLAG tagged human cDNA sequence into exon1 of the Smad2 gene. Resulting allele expresses full length human Smad2 in place of endogenous Smad2. |
Phenotypic information | Embryonic lethal at 8.5 dpc. |
Breeding history | Backcrossed to 129/SvEv. |
References |
|
Homozygous fertile | no |
Homozygous viable | no |
Homozygous matings required | no |
Immunocompromised | not known |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Familial thoracic aortic aneurysm and aortic dissection / Orphanet_91387
Literature references
- Mice exclusively expressing the short isoform of Smad2 develop normally and are viable and fertile.;Dunn N Ray, Koonce Chad H, Anderson Dorian C, Islam Ayesha, Bikoff Elizabeth K, Robertson Elizabeth J, ;2005;Genes & development;19;152-63; 15630024
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).