STOCK Invsinv/H

Status

Available to order

EMMA IDEM:02515
International strain nameSTOCK Invsinv/H
Alternative nameINV
Strain typeTransgenic Strains
Allele/Transgene symbolInvsinv,
Gene/Transgene symbolInvs

Information from provider

ProviderElizabeth Robertson
Provider affiliationSir William Dunn School of Pathology, University of Oxford
Additional ownerFor further information contact Martin Fray, FESA Manager. m.fray@har.mrc.ac.uk
Genetic informationThe inv mutation was caused by a transgene insertion mutagenic event that resulted in a small duplication and a 47-kb deletion. This deletion eliminated exons 3-11, causing a frameshift in the remaining coding segment.
Phenotypic informationThe mutation is maintained on an albino background and heterozygous carriers identified by their slightly pigmented coat colour due to low level expression of tyrosinase activity. Homozygous embryos survive gestation but die at birth due to defects in cardiac development associated with situs inversus.
Breeding historyOutcrossed to CD1.
References
  • Reversal of left-right asymmetry: a situs inversus mutation.;Yokoyama T, Copeland N G, Jenkins N A, Montgomery C A, Elder F F, Overbeek P A, ;1993;Science (New York, N.Y.);260;679-82; 8480178
Homozygous fertileno
Homozygous viableno
Homozygous matings requiredno
Immunocompromisednot known

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

MGI allele-associated human disease models

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • abnormal liver morphology / MGI
  • abnormal heart morphology / MGI
  • double outlet right ventricle / MGI
  • abnormal atrioventricular cushion morphology / MGI
  • abnormal intestine morphology / MGI
  • left-sided isomerism / MGI
  • dextrocardia / MGI
  • abnormal spleen morphology / MGI
  • spleen hypoplasia / MGI
  • abnormal pancreas morphology / MGI
  • situs inversus / MGI
  • situs ambiguus / MGI
  • left pulmonary isomerism / MGI
  • transposition of great arteries / MGI
  • abnormal vena cava morphology / MGI
  • aortic valve stenosis / MGI
  • left atrial isomerism / MGI
  • atrial situs inversus / MGI
  • right-sided stomach / MGI
  • lung situs inversus / MGI
  • abdominal situs ambiguus / MGI
  • kidney cortex cysts / MGI
  • jaundice / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • postnatal lethality / MGI
  • abnormal kidney morphology / MGI
  • dilated renal tubules / MGI
  • nephrocalcinosis / MGI
  • kidney failure / MGI
  • kidney cysts / MGI
  • increased kidney weight / MGI
  • abnormal primitive node morphology / MGI
  • abnormal direction of embryo turning / MGI
  • abnormal kidney pelvis morphology / MGI
  • abnormal direction of heart looping / MGI
  • dilated kidney collecting duct / MGI
  • abnormal biliary tract morphology / MGI
  • abnormal pancreatic islet morphology / MGI
  • abnormal renal glomerulus morphology / MGI
  • renal/urinary system phenotype / MGI
  • respiratory system phenotype / MGI
  • pancreatic islet hyperplasia / MGI
  • increased blood urea nitrogen level / MGI
  • slow postnatal weight gain / MGI
  • abnormal motile primary cilium physiology / MGI
  • dilated proximal convoluted tubules / MGI
  • dilated pancreatic duct / MGI
  • abnormal pancreatic acinus morphology / MGI
  • abnormal pancreatic acinar cell morphology / MGI
  • decreased pancreatic acinar cell number / MGI
  • disorganized pancreatic islets / MGI
  • kidney medulla cysts / MGI
  • kidney corticomedullary cysts / MGI
  • abnormal loop of Henle descending limb morphology / MGI
  • abnormal loop of Henle ascending limb thick segment morphology / MGI
  • proximal convoluted tubule brush border loss / MGI
  • abnormal kidney interstitium morphology / MGI
  • increased glomerular capsule space / MGI
  • renal glomerulus cysts / MGI
  • abnormal embryonic cilium location or orientation / MGI
  • right pulmonary isomerism / MGI
  • right aortic arch / MGI
  • double aortic arch / MGI
  • aorta hypoplasia / MGI

Literature references

  • Reversal of left-right asymmetry: a situs inversus mutation.;Yokoyama T, Copeland N G, Jenkins N A, Montgomery C A, Elder F F, Overbeek P A, ;1993;Science (New York, N.Y.);260;679-82; 8480178

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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