STOCK Lhx1tm1Bhr/H

Status

Available to order

EMMA IDEM:02519
International strain nameSTOCK Lhx1tm1Bhr/H
Alternative nameLim-1 (Lhx-1)
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolLhx1tm1Bhr,
Gene/Transgene symbolLhx1

Information from provider

ProviderElizabeth Robertson
Provider affiliationSir William Dunn School of Pathology, University of Oxford
Additional ownerFor further information contact Martin Fray, FESA Manager. m.fray@har.mrc.ac.uk
Genetic informationLoss of function mutation at the Lhx1 (Lim-1) locus. Coding sequence replaced by neo expression vector. Mutation is useful for studying gastrulation of the mouse embryo and specification of the definitive endoderm.
Phenotypic informationHomozygous lethal at day 10 of gestation.
Breeding historyOutcrossed to CD1.
References
  • Requirement for Lim1 in head-organizer function.;Shawlot W, Behringer R R, ;1995;Nature;374;425-30; 7700351
Homozygous fertileno
Homozygous viableno
Homozygous matings requiredno
Immunocompromisednot known

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

MGI phenotypes (allele matching)
  • absent kidney / MGI
  • abnormal brain development / MGI
  • abnormal spinal cord morphology / MGI
  • decreased embryo size / MGI
  • incomplete embryo turning / MGI
  • abnormal allantois morphology / MGI
  • abnormal gastrulation movements / MGI
  • abnormal egg cylinder morphology / MGI
  • absent ovary / MGI
  • abnormal primitive node morphology / MGI
  • dilated allantois / MGI
  • small allantois / MGI
  • agonadal / MGI
  • abnormal hindbrain development / MGI
  • absent testes / MGI
  • acephaly / MGI
  • perinatal lethality, complete penetrance / MGI
  • embryonic lethality during organogenesis, incomplete penetrance / MGI
  • absent midbrain / MGI
  • embryonic-extraembryonic boundary constriction / MGI
  • absent forebrain / MGI
  • rostral-caudal axis duplication / MGI
  • absent prechordal mesoderm / MGI
  • abnormal anterior head development / MGI
  • abnormal primitive streak formation / MGI
  • abnormal rostral-caudal axis patterning / MGI
  • abnormal primitive streak elongation / MGI
  • abnormal female reproductive system morphology / MGI
  • abnormal male reproductive system morphology / MGI
  • absent ureter / MGI
  • absent metanephros / MGI

Literature references

  • Requirement for Lim1 in head-organizer function.;Shawlot W, Behringer R R, ;1995;Nature;374;425-30; 7700351

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).