- absent kidney / MGI
- abnormal brain development / MGI
- abnormal spinal cord morphology / MGI
- decreased embryo size / MGI
- incomplete embryo turning / MGI
- abnormal allantois morphology / MGI
- abnormal gastrulation movements / MGI
- abnormal egg cylinder morphology / MGI
- absent ovary / MGI
- abnormal primitive node morphology / MGI
- dilated allantois / MGI
- small allantois / MGI
- agonadal / MGI
- abnormal hindbrain development / MGI
- absent testes / MGI
- acephaly / MGI
- perinatal lethality, complete penetrance / MGI
- embryonic lethality during organogenesis, incomplete penetrance / MGI
- absent midbrain / MGI
- embryonic-extraembryonic boundary constriction / MGI
- absent forebrain / MGI
- rostral-caudal axis duplication / MGI
- absent prechordal mesoderm / MGI
- abnormal anterior head development / MGI
- abnormal primitive streak formation / MGI
- abnormal rostral-caudal axis patterning / MGI
- abnormal primitive streak elongation / MGI
- abnormal female reproductive system morphology / MGI
- abnormal male reproductive system morphology / MGI
- absent ureter / MGI
- absent metanephros / MGI
STOCK Lhx1tm1Bhr/H
Status | Available to order |
EMMA ID | EM:02519 |
International strain name | STOCK Lhx1tm1Bhr/H |
Alternative name | Lim-1 (Lhx-1) |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Lhx1tm1Bhr, |
Gene/Transgene symbol | Lhx1 |
Information from provider
Provider | Elizabeth Robertson |
Provider affiliation | Sir William Dunn School of Pathology, University of Oxford |
Additional owner | For further information contact Martin Fray, FESA Manager. m.fray@har.mrc.ac.uk |
Genetic information | Loss of function mutation at the Lhx1 (Lim-1) locus. Coding sequence replaced by neo expression vector. Mutation is useful for studying gastrulation of the mouse embryo and specification of the definitive endoderm. |
Phenotypic information | Homozygous lethal at day 10 of gestation. |
Breeding history | Outcrossed to CD1. |
References |
|
Homozygous fertile | no |
Homozygous viable | no |
Homozygous matings required | no |
Immunocompromised | not known |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI phenotypes (allele matching)
Literature references
- Requirement for Lim1 in head-organizer function.;Shawlot W, Behringer R R, ;1995;Nature;374;425-30; 7700351
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