STOCK Tg(Prnp-PRNP*6OR)K6M6Pcg/H
Status | Available to order |
EMMA ID | EM:02538 |
International strain name | STOCK Tg(Prnp-PRNP*6OR)K6M6Pcg/H |
Alternative name | Tg(KuPrP)K6M6 |
Strain type | Transgenic Strains |
Allele/Transgene symbol | Tg(Prnp-PRNP*6OR)K6M6Pcg |
Gene/Transgene symbol | Tg(Prnp-PRNP*6OR)K6M6Pcg |
Information from provider
Provider | Peter Griffiths |
Provider affiliation | Department of Pathology and Host Susceptibility, Animal Health and Veterinary Laboratories Agency (AHVLA) |
Genetic information | Tg(KuPrP)K6M6 mice were generated using a ~12 kb transgene, based on the pPrPHG plasmid containing kudu Prnp open reading frame sequence, which was microinjected into pronuclear stage FVB/NIco fertilised oocytes. |
Phenotypic information | Overexpression of transgenic kudu PRNP (PrPC) protein in brain and other tissues, in order to confer increased susceptibility to TSE diseases, including BSE, compared to wild-type mice. |
Breeding history | Inbred to 4 generations. Brother and sister matings. |
References | None available |
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | yes |
Immunocompromised | not known |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
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