- reduced long term potentiation / MGI
- abnormal CNS synaptic transmission / MGI
- abnormal inhibitory postsynaptic potential / MGI
- abnormal inhibitory postsynaptic currents / MGI
- behavior/neurological phenotype / MGI
- decreased brain copper level / MGI
- tremors / MGI
- abnormal cerebellum morphology / MGI
- decreased Purkinje cell number / MGI
STOCK Prnptm1Cwe Tg(Prnp-PRNP*6OR)K6M16Pcg/H
Status | Available to order |
EMMA ID | EM:02539 |
International strain name | STOCK Prnptm1Cwe Tg(Prnp-PRNP*6OR)K6M16Pcg/H |
Alternative name | Tg(KuPrP)K6M16 |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Prnptm1Cwe, |
Gene/Transgene symbol | Prnp |
Information from provider
Provider | Peter Griffiths |
Provider affiliation | Department of Pathology and Host Susceptibility, Animal Health and Veterinary Laboratories Agency (AHVLA) |
Genetic information | Tg(KuPrP)K6M16 mice were generated using a ~12 kb transgene, based on the pPrPHG plasmid containing kudu Prnp open reading frame sequence, which was microinjected into pronuclear stage FVB/NIco fertilised oocytes. |
Phenotypic information | Overexpression of transgenic kudu PrPC in brain and other tissues, in order to confer increased susceptibility to TSE diseases, including BSE, compared to wild-type mice. Tg(KuPrP)K6M16 mice are hemizygous for the transgene. |
Breeding history | Bred to 4 generations. Tg(KuPrP)K6M16 mice were bred with PrP knockout mice (Prnp 0/0; Zurich I, Bueler et al. 1992, Nature 356, 577-582) and maintained as a hemizygous line. |
References | None available |
Homozygous fertile | not known |
Homozygous viable | not known |
Homozygous matings required | no |
Immunocompromised | not known |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Animals used for archiving | heterozygous mixed, heterozygous mixed |
Breeding at archiving centre | Intercrossed. Mice are on a mixed genetic background. |
Stage of embryos | 4/8-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Inherited Creutzfeldt-Jakob disease / Orphanet_282166
- Familial Alzheimer-like prion disease / Orphanet_280397
- Huntington disease-like 1 / Orphanet_157941
- PrP systemic amyloidosis / Orphanet_397606
- Fatal familial insomnia / Orphanet_466
- Gerstmann-Straussler-Scheinker syndrome / Orphanet_356
- Sporadic fatal insomnia / Orphanet_586130
MGI phenotypes (allele matching)
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