STOCK Prnptm1Cwe Tg(Prnp-PRNP*6OR)K6M16Pcg/H

Status

Available to order

EMMA IDEM:02539
International strain nameSTOCK Prnptm1Cwe Tg(Prnp-PRNP*6OR)K6M16Pcg/H
Alternative nameTg(KuPrP)K6M16
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolPrnptm1Cwe,
Gene/Transgene symbolPrnp

Information from provider

ProviderPeter Griffiths
Provider affiliationDepartment of Pathology and Host Susceptibility, Animal Health and Veterinary Laboratories Agency (AHVLA)
Genetic informationTg(KuPrP)K6M16 mice were generated using a ~12 kb transgene, based on the pPrPHG plasmid containing kudu Prnp open reading frame sequence, which was microinjected into pronuclear stage FVB/NIco fertilised oocytes.
Phenotypic informationOverexpression of transgenic kudu PrPC in brain and other tissues, in order to confer increased susceptibility to TSE diseases, including BSE, compared to wild-type mice. Tg(KuPrP)K6M16 mice are hemizygous for the transgene.
Breeding historyBred to 4 generations. Tg(KuPrP)K6M16 mice were bred with PrP knockout mice (Prnp 0/0; Zurich I, Bueler et al. 1992, Nature 356, 577-582) and maintained as a hemizygous line.
ReferencesNone available
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requiredno
Immunocompromisednot known

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archivingheterozygous mixed, heterozygous mixed
Breeding at archiving centreIntercrossed. Mice are on a mixed genetic background.
Stage of embryos4/8-cell

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • reduced long term potentiation / MGI
  • abnormal CNS synaptic transmission / MGI
  • abnormal inhibitory postsynaptic potential / MGI
  • abnormal inhibitory postsynaptic currents / MGI
  • behavior/neurological phenotype / MGI
  • decreased brain copper level / MGI
  • tremors / MGI
  • abnormal cerebellum morphology / MGI
  • decreased Purkinje cell number / MGI

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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