C57BL/6-Dpp4tm1Nwa/Orl
Status | Available to order |
EMMA ID | EM:02577 |
International strain name | C57BL/6-Dpp4tm1Nwa/Orl |
Alternative name | C57Bl/6_DPP4-/- |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Dpp4tm1Nwa, |
Gene/Transgene symbol | Dpp4 |
Information from provider
Provider | Didier MARGUET |
Provider affiliation | Centre D |
Genetic information | Deletion in the CD26/Dpp4 gene which inactivated the expression of the DPP4 enzyme. A 2.3-kb PstI-SphI fragment containing exons 1 and 2, was replaced with the non floxed PGKNeo cassette. |
Phenotypic information | Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26/Dpp4. |
Breeding history | Since its origin, the strain has been inbred on C57BL/6 strain. |
References |
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Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Animals used for archiving | homozygous C57BL/6J |
Breeding at archiving centre | We have frozen sperm under two protocols: - MTG protocol (heterozygous males) - CARD protocol (homozygous males). Please inform us if you have a preference for one of them when you submit a request. |
Disease and phenotype information
MGI phenotypes (allele matching)
Literature references
- Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26.;Marguet D, Baggio L, Kobayashi T, Bernard A M, Pierres M, Nielsen P F, Ribel U, Watanabe T, Drucker D J, Wagtmann N, ;2000;Proceedings of the National Academy of Sciences of the United States of America;97;6874-9; 10823914
- Prediabetes blunts DPP4 genetic control of postprandial glycaemia and insulin secretion.;Patarrão Rita S, Duarte Nádia, Coelho Inês, Ward Joey, Ribeiro Rogério T, Meneses Maria João, Andrade Rita, Costa João, Correia Isabel, Boavida José Manuel, Duarte Rui, Gardete-Correia Luís, Medina José Luís, Pell Jill, Petrie John, Raposo João F, Macedo Maria Paula, Penha-Gonçalves Carlos, ;2022;Diabetologia;65;861-871; 35190847
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