STOCK EpoTg(TAg/Epo)134.3LCPjr/H
| Status | Available to order |
| EMMA ID | EM:02595 |
| International strain name | STOCK EpoTg(TAg/Epo)134.3LCPjr/H |
| Alternative name | Epo |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(TAg/Epo)134.3LCPjr, |
| Gene/Transgene symbol | Epo |
Information from provider
| Provider | Patrick Maxwell |
| Provider affiliation | Wellcome Trust Centre for Human Genetics, University of Oxford |
| Genetic information | pBS construct with 16.5 kb of mouse Epo, including the entire Epo gene. A 2.7 kb Bgl1/BamH1 fragment of Sv40 DNA encoding "T" antigen was inserted into the 5'-UTR of the Epo gene. |
| Phenotypic information | The insertion of SV40 T antigen sequence in the 5'-UTR of the native Epo gene results in very little Epo production from the fusion gene. Homozygotes have incomplete Epo deficiency and are anaemic. The mice express SV40 T antigen in a regulated fashion (by anaemia and hypoxia) in Epo-producing cells. |
| Breeding history | Outcrossed to C57BL/6J. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal dominant secondary polycythemia / Orphanet_247511
Literature references
- Identification of the renal erythropoietin-producing cells using transgenic mice.;Maxwell P H, Osmond M K, Pugh C W, Heryet A, Nicholls L G, Tan C C, Doe B G, Ferguson D J, Johnson M H, Ratcliffe P J, ;1993;Kidney international;44;1149-62; 8264149