STOCK Tg(PRNP)2019Pcg/H
Status | Available to order |
EMMA ID | EM:02600 |
International strain name | STOCK Tg(PRNP)2019Pcg/H |
Alternative name | Tg(BoPrP)2019 |
Strain type | Transgenic Strains |
Allele/Transgene symbol | Tg(PRNP)2019Pcg |
Gene/Transgene symbol | Tg(PRNP)2019Pcg |
Information from provider
Provider | Peter Griffiths |
Provider affiliation | Department of Pathology and Host Susceptibility, Animal Health and Veterinary Laboratories Agency (AHVLA) |
Genetic information | A 60 kb DNA fragment, derived from a bovine bacterial artificial chromosome (BAC) library clone (D18330) containing the bovine PrP gene locus (GenBank sequence AJ298878; Hills et al., 2001), was used to microinject pronuclear stage FVB/NIco fertilised oocytes. |
Phenotypic information | Overexpression of transgenic bovine PrPC in brain and other tissues, in order to confer increased susceptibility to TSE diseases, including BSE, compared to wild-type mice. |
Breeding history | Inbred to 5 generations. Brother and sister matings. |
References | None available |
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | yes |
Immunocompromised | not known |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Animals used for archiving | homozygous FVB/NIco x (C57BL/6 x 129/SvEv), homozygous FVB/NIco x (C57BL/6 x 129/SvEv) |
Breeding at archiving centre | None. Plugged females were received for embryo harvest. |
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