STOCK Tg(PRNP)2019Pcg/H

Status

Available to order

EMMA IDEM:02600
International strain nameSTOCK Tg(PRNP)2019Pcg/H
Alternative nameTg(BoPrP)2019
Strain typeTransgenic Strains
Allele/Transgene symbolTg(PRNP)2019Pcg
Gene/Transgene symbolTg(PRNP)2019Pcg

Information from provider

ProviderPeter Griffiths
Provider affiliationDepartment of Pathology and Host Susceptibility, Animal Health and Veterinary Laboratories Agency (AHVLA)
Genetic informationA 60 kb DNA fragment, derived from a bovine bacterial artificial chromosome (BAC) library clone (D18330) containing the bovine PrP gene locus (GenBank sequence AJ298878; Hills et al., 2001), was used to microinject pronuclear stage FVB/NIco fertilised oocytes.
Phenotypic informationOverexpression of transgenic bovine PrPC in brain and other tissues, in order to confer increased susceptibility to TSE diseases, including BSE, compared to wild-type mice.
Breeding historyInbred to 5 generations. Brother and sister matings.
ReferencesNone available
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredyes
Immunocompromisednot known

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archivinghomozygous FVB/NIco x (C57BL/6 x 129/SvEv), homozygous FVB/NIco x (C57BL/6 x 129/SvEv)
Breeding at archiving centreNone. Plugged females were received for embryo harvest.

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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