STOCK Tg(Prnp/PRNP*ARR)FM18Pcg/H
Status | Available to order |
EMMA ID | EM:02604 |
International strain name | STOCK Tg(Prnp/PRNP*ARR)FM18Pcg/H |
Alternative name | Tg(OvPrP)FM18 |
Strain type | Transgenic Strains |
Allele/Transgene symbol | Tg(Prnp/PRNP*ARR)FM18Pcg |
Gene/Transgene symbol | Tg(Prnp/PRNP*ARR)FM18Pcg |
Information from provider
Provider | Peter Griffiths |
Provider affiliation | Department of Pathology and Host Susceptibility, Animal Health and Veterinary Laboratories Agency (AHVLA) |
Genetic information | An ~12 kb transgene, comprised of chimeric DNA sequence encoding a sheep PrP (ARR allele) coding region and mouse PrP gene promoter and 3'UTR, was used to microinject pronuclear stage FVB/NIco fertilised oocytes. |
Phenotypic information | Overexpression of transgenic ovine PrPC in brain and other tissues in order to confer increased susceptibility to TSE diseases compared to wild-type mice. |
Breeding history | Inbred to 5 generations. Brother and sister matings. |
References | None available |
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | yes |
Immunocompromised | not known |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Animals used for archiving | homozygous FVB/NIco x (C57BL/6 x 129/SvEv) |
Breeding at archiving centre | None |
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