STOCK Tg(Prnp/PRNP*ARR)FM18Pcg/H

Status

Available to order

EMMA IDEM:02604
International strain nameSTOCK Tg(Prnp/PRNP*ARR)FM18Pcg/H
Alternative nameTg(OvPrP)FM18
Strain typeTransgenic Strains
Allele/Transgene symbolTg(Prnp/PRNP*ARR)FM18Pcg
Gene/Transgene symbolTg(Prnp/PRNP*ARR)FM18Pcg

Information from provider

ProviderPeter Griffiths
Provider affiliationDepartment of Pathology and Host Susceptibility, Animal Health and Veterinary Laboratories Agency (AHVLA)
Genetic informationAn ~12 kb transgene, comprised of chimeric DNA sequence encoding a sheep PrP (ARR allele) coding region and mouse PrP gene promoter and 3'UTR, was used to microinject pronuclear stage FVB/NIco fertilised oocytes.
Phenotypic informationOverexpression of transgenic ovine PrPC in brain and other tissues in order to confer increased susceptibility to TSE diseases compared to wild-type mice.
Breeding historyInbred to 5 generations. Brother and sister matings.
ReferencesNone available
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredyes
Immunocompromisednot known

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archivinghomozygous FVB/NIco x (C57BL/6 x 129/SvEv)
Breeding at archiving centreNone

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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