- increased anxiety-related response / MGI
- decreased exploration in new environment / MGI
- decreased vertical activity / MGI
- abnormal behavior / MGI
- behavior/neurological phenotype / MGI
- abnormal craniofacial morphology / MGI
- short snout / MGI
- broad nasal bridge / MGI
- small testis / MGI
- abnormal embryo development / MGI
- reduced male fertility / MGI
- reduced female fertility / MGI
- testicular atrophy / MGI
- nervous system phenotype / MGI
- prenatal lethality, incomplete penetrance / MGI
- embryonic lethality, incomplete penetrance / MGI
- absent embryonic epiblast / MGI
- decreased embryonic epiblast cell proliferation / MGI
STOCK Gtf2itm1Vcam/Cnbc
Status | Available to order |
EMMA ID | EM:02617 |
International strain name | STOCK Gtf2itm1Vcam/Cnbc |
Alternative name | GTF2I-2loxP |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Gtf2itm1Vcam, |
Gene/Transgene symbol | Gtf2i |
Information from provider
Provider | Victoria Campuzano |
Provider affiliation | GENETIC UNIT, CEXS, UNIVERSITAT POMPEU FABRA |
Genetic information | Targeting construct is derived from 129 DNA. The deletion spans part of intron 1, exon 2 with start codon ATG, and part of intron 2. |
Phenotypic information | Sensitive to high sounds. Special facial morphology. Partial viability and fertility of homozygous mutants. |
References |
|
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
Animals used for archiving | heterozygous CD-1 outbred stock (syn.: outbr. CD-1 or CD1, Swiss CD-1 or CD1, ICR(CD-1), etc.), wild-type CD-1 outbred stock (syn.: outbr. CD-1 or CD1, Swiss CD-1 or CD1, ICR(CD-1), etc.) |
Stage of embryos | 8-cell |
Disease and phenotype information
MGI allele-associated human disease models
MGI phenotypes (allele matching)
Literature references
- Essential role of the N-terminal region of TFII-I in viability and behavior.;Lucena Jaume, Pezzi Susana, Aso Ester, Valero Maria C, Carreiro Candelas, Dubus Pierre, Sampaio Adriana, Segura Maria, Barthelemy Isabel, Zindel Marc Y, Sousa Nuno, Barbero José L, Maldonado Rafael, Pérez-Jurado Luis A, Campuzano Victoria, ;2010;BMC medical genetics;11;61; 20403157
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