STOCK Scnn1gtm1.1Hum/Orl
Status | Available to order |
EMMA ID | EM:04400 |
International strain name | STOCK Scnn1gtm1.1Hum/Orl |
Alternative name | Scnn1g lox/lox |
Strain type | Targeted Mutant Strains : Conditional mutation |
Allele/Transgene symbol | Scnn1gtm1.1Hum, |
Gene/Transgene symbol | Scnn1g |
Information from provider
Provider | Edith Hummler |
Provider affiliation | Pharmacology & Toxicology, University of Lausanne |
Genetic information | An frt-flanked neo cassette with a 3' loxP site was inserted upstream of exon 2, and an additional loxP site was inserted downstream of exon 2. Germ line, flp-recombination was used to remove the neo cassette. |
Phenotypic information | No phenotype. |
References |
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Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Animals used for archiving | homozygous , wild-type C57BL/6N |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Generalized pseudohypoaldosteronism type 1 / Orphanet_171876
- Liddle syndrome / Orphanet_526
- Idiopathic bronchiectasis / Orphanet_60033
Literature references
- Conditional gene targeting of the ENaC subunit genes Scnn1b and Scnn1g.;Mérillat Anne-Marie, Charles Roch-Philippe, Porret Andrée, Maillard Marc, Rossier Bernard, Beermann Friedrich, Hummler Edith, ;2009;American journal of physiology. Renal physiology;296;F249-56; 19036848
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