STOCK Tg(tetO-AGTR1,-lacZ)1Aco/Cnbc

Status

Available to order

EMMA IDEM:04643
International strain nameSTOCK Tg(tetO-AGTR1,-lacZ)1Aco/Cnbc
Alternative nameZhAT1Rwt1
Strain typeTransgenic Strains
Allele/Transgene symbolTg(tetO-AGTR1, -lacZ)1Aco
Gene/Transgene symbolTg(tetO-AGTR1,-lacZ)1Aco

Information from provider

ProviderJustin Ainscough
Provider affiliationCentral Biomedical Services, University of Leeds
Genetic informationA lacZ reporter gene and the human angiotensin II type 1 receptor are expressed under control of a bidirectional minimal CMV promoter linked to a tet response element (TRE). Gene expression is induced in the presence of a transactivator molecule (tTA or rtTA), and can be regulated by doxycycline.
Phenotypic informationNo phenotype in uninduced state. Induction of hAT1R expression in adult cardiomyocytes by crossing with alphaMHC tTA transactivator mice causes blood pressure-independent cardiac hypertrophy. Effects of activation in other tissues have not been tested.
Breeding historyThe line was crossed with FVB transactivator mice and subsequently backcrossed for at least four generations onto C57BL/6. Currently maintained by inbreeding.
References
  • Angiotensin II type-1 receptor activation in the adult heart causes blood pressure-independent hypertrophy and cardiac dysfunction.;Ainscough Justin F X, Drinkhill Mark J, Sedo Alicia, Turner Neil A, Brooke David A, Balmforth Anthony J, Ball Stephen G, ;2009;Cardiovascular research;81;592-600; 18703536
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain
Animals used for archivingheterozygous C57BL/6J

Literature references

  • Angiotensin II type-1 receptor activation in the adult heart causes blood pressure-independent hypertrophy and cardiac dysfunction.;Ainscough Justin F X, Drinkhill Mark J, Sedo Alicia, Turner Neil A, Brooke David A, Balmforth Anthony J, Ball Stephen G, ;2009;Cardiovascular research;81;592-600; 18703536

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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