STOCK Tyrc-em/Cnbc

Status

Available to order

EMMA IDEM:04769
International strain nameSTOCK Tyrc-em/Cnbc
Alternative nameTyr "extreme dilution mottled":NMRI/Hsd
Strain typeSpontaneous
Allele/Transgene symbolTyrc,
Gene/Transgene symbolTyr

Information from provider

ProviderLluis Montoliu
Provider affiliationDepartamento de Biologia Molecular y Celular, CNB-CSIC, Centro Nacional de Biotecnologia
Additional ownerThe original Tyr extreme dilution mottled allele is kept at MRC-Harwell, FESA. Person of contact: Martin Fray
Genetic informationMice carrying the Tyrc-em "extreme dilution mottled" allele were imported as live animals from MRC Harwell (FESA, Peter Glenister) in 2001 after rescuing the line from frozen embryos. Genotype received included: Tyrc-em/Tyr+. Since then they were bred to albino outbred Hsd:NMRI mice and eventually maintained as homozygous Tyrc-em/Tyrc-em. The Tyrc-em allele is a mutation that occurred in the Tyrc-m stock. The molecular basis was established in 2005, by the laboratory of Lluis Montoliu (Lavado et al. 2005 JBC).
Phenotypic informationTyrc-em "extreme dilution mottled" mice have a pale almost-albino coat, with some pigmentation in ears, and ruby eyes. Homozygous are darker (more pigmented) than heterozygous, which appear to be almost-albino, with the exception of a somewhat "dirty white" coat colour.
Breeding historySince 2001, the Tyrc-em extreme dilution mottled allele has been bred and maintained, as homozygous, in albino outbred Hsd:NMRI mouse strain.
References
  • Molecular basis of the extreme dilution mottled mouse mutation: a combination of coding and noncoding genomic alterations.;Lavado Alfonso, Olivares Concepción, García-Borrón José Carlos, Montoliu Lluís, ;2005;The Journal of biological chemistry;280;4817-24; 15572362
  • Modification of c-locus alleles - Mcm;Phillips RJS;1980;Mouse News Lett.;62;51-2;
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain
Animals used for archivinghomozygous NMRI, wild-type NMRI
Stage of embryos8-cell

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • diluted coat color / MGI
  • abnormal eye pigmentation / MGI
  • variegated coat color / MGI
  • absent coat pigmentation / MGI
  • abnormal coat/hair pigmentation / MGI
  • absent eye pigmentation / MGI
  • abnormal coat appearance / MGI
  • decreased eye pigmentation / MGI
  • mottled coat / MGI
  • belly spot / MGI
  • hypopigmentation / MGI
  • variegated eye pigmentation pattern / MGI
  • decreased ear pigmentation / MGI

Literature references

  • Molecular basis of the extreme dilution mottled mouse mutation: a combination of coding and noncoding genomic alterations.;Lavado Alfonso, Olivares Concepción, García-Borrón José Carlos, Montoliu Lluís, ;2005;The Journal of biological chemistry;280;4817-24; 15572362
  • Modification of c-locus alleles - Mcm;Phillips RJS;1980;Mouse News Lett.;62;51-2;

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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