C3HeB/FeJ-Jag1Yo/IegWtsiCnbc

Status

Available to order

EMMA IDEM:04899
International strain nameC3HeB/FeJ-Jag1Yo/IegWtsiCnbc
Alternative nameYoyo Jag1
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolJag1Yo,
Gene/Transgene symbolJag1

Information from provider

ProviderKaren Steel
Provider affiliationWellcome Trust Sanger Institute
Additional ownerProf. M. Hrabé de Angelis, Helmholtz Zentrum München, Neuherberg, Germany
Genetic informationA new nonsense mutation induced by ENU in Jag1.
Phenotypic informationA new ENU-induced semi-dominant Jag1 mutation leading to truncation of posterior and/or anterior semicircular canals and reduced rows of outer hair cells in the inner ear in heterozygotes. Homozygotes die in mid-gestation.
Breeding historyOriginated from ENU mutagenesis programme in Helmholtz Zentrum Munich, on a C3HeB/FeJ background and bred on the same background within a closed colony or backcrossed to C3HeB/FeJ ever since.
References
  • Hush puppy: a new mouse mutant with pinna, ossicle, and inner ear defects.;Pau Henry, Fuchs Helmut, de Angelis Martin Hrabé, Steel Karen P, ;2005;The Laryngoscope;115;116-24; 15630379
Homozygous fertileno
Homozygous viableno
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • abnormal posterior semicircular canal morphology / MGI
  • abnormal superior semicircular canal morphology / MGI
  • decreased cochlear outer hair cell number / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI

Literature references

  • Hush puppy: a new mouse mutant with pinna, ossicle, and inner ear defects.;Pau Henry, Fuchs Helmut, de Angelis Martin Hrabé, Steel Karen P, ;2005;The Laryngoscope;115;116-24; 15630379

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).