- decreased bone mineral density / MGI
- abnormal trabecular bone morphology / MGI
- decreased compact bone thickness / MGI
- decreased bone mass / MGI
- increased osteoclast cell number / MGI
- increased bone resorption / MGI
- osteoporosis / MGI
- increased body weight / MGI
- increased circulating insulin level / MGI
- improved glucose tolerance / MGI
- homeostasis/metabolism phenotype / MGI
B6.129P2-Iapptm1Sgm/Kctt
Status | Available to order |
EMMA ID | EM:05269 |
International strain name | B6.129P2-Iapptm1Sgm/Kctt |
Alternative name | Iapp knock-out mice |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Iapptm1Sgm, |
Gene/Transgene symbol | Iapp |
Information from provider
Provider | Samuel Gebre-Medhin |
Provider affiliation | Experimental Medical Science, Lund University |
Genetic information | Targeting construct is derived from BALB/c DNA. Entire coding DNA sequence for mature IAPP is replaced by neomycin resistance gene. |
Phenotypic information | Augmented insulin secretion. Reduced nociception. Reduced bone mineral density. |
Breeding history | 8 backcrosses to C57BL. |
References |
|
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | not known |
Information from EMMA
Archiving centre | Karolinska Institutet, Stockholm, Sweden |
Animals used for archiving | homozygous 0, heterozygous C57BL/6J |
Breeding at archiving centre | No breeding at Karolinska Inst. |
Stage of embryos | 2-cell |
Disease and phenotype information
MGI phenotypes (allele matching)
Literature references
- Increased insulin secretion and glucose tolerance in mice lacking islet amyloid polypeptide (amylin).;Gebre-Medhin S, Mulder H, Pekny M, Westermark G, Törnell J, Westermark P, Sundler F, Ahrén B, Betsholtz C, ;1998;Biochemical and biophysical research communications;250;271-7; 9753619
- Reduced nociceptive behavior in islet amyloid polypeptide (amylin) knockout mice.;Gebre-Medhin S, Mulder H, Zhang Y, Sundler F, Betsholtz C, ;1998;Brain research. Molecular brain research;63;180-3; 9838101
- Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo.;Dacquin Romain, Davey Rachel A, Laplace Catherine, Levasseur Régis, Morris Howard A, Goldring Steven R, Gebre-Medhin Samuel, Galson Deborah L, Zajac Jeffrey D, Karsenty Gérard, ;2004;The Journal of cell biology;164;509-14; 14970190
- Amylin-Calcitonin receptor signaling in the medial preoptic area mediates affiliative social behaviors in female mice.;Fukumitsu Kansai, Kaneko Misato, Maruyama Teppo, Yoshihara Chihiro, Huang Arthur J, McHugh Thomas J, Itohara Shigeyoshi, Tanaka Minoru, Kuroda Kumi O, ;2022;Nature communications;13;709; 35136064
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