STOCK Halhis/H

Status

Available to order

EMMA IDEM:05325
International strain nameSTOCK Halhis/H
Alternative nameHistidinaemic
Strain typeSpontaneous
Allele/Transgene symbolHalhis,
Gene/Transgene symbolHal

Information from provider

ProviderClare Selden
Provider affiliationCentre for Hepatology, UCL Medical School
Genetic informationA single base mutation in the histidase gene which blocks the conversion of histidine to urocanic acid. The guanine to adenine transition which occurs in the histidase gene on mouse chrom. 10 leads to an amino acid substitution from arginine to glutamine. This mutation leads to an unstable form of the histidase (histidine ammonia lyase) enzyme.
Phenotypic informationCoat Colour: grey. Behaviour: neurotic. Homozygotes, heterozygotes and wild-types are not visibly distinguishable, but a urine test can rapidly screen wild-types from homozygotes. HPLC quantification of histidine in urine can distinguish heterozygotes from homozygotes.
Breeding historyA naturally occurring mutation in a strain of wild mice. This has been backcrossed to C57BL/6J for several generations.
References
  • Histidinaemia in mouse and man.;Bulfield G, Kacser H, ;1974;Archives of disease in childhood;49;545-52; 4546820
  • Histidinemia in mice: a metabolic defect treated using a novel approach to hepatocellular transplantation.;Selden C, Calnan D, Morgan N, Wilcox H, Carr E, Hodgson H J, ;1995;Hepatology (Baltimore, Md.);21;1405-12; 7537713
  • Assignment of histidase-regulating locus to chromosome 10 of the mouse.;Arfin S M, Hanford W C, Taylor B A, ;1979;Biochemical genetics;17;529-35; 518536
  • Histidase and histidinemia. Clinical and molecular considerations.;Taylor R G, Levy H L, McInnes R R, ;1991;Molecular biology & medicine;8;101-16; 1943682
  • Localization of histidase to human chromosome region 12q22----q24.1 and mouse chromosome region 10C2----D1.;Taylor R G, García-Heras J, Sadler S J, Lafreniere R G, Willard H F, Ledbetter D H, McInnes R R, ;1991;Cytogenetics and cell genetics;56;178-81; 2055114
  • Cloning and expression of rat histidase. Homology to two bacterial histidases and four phenylalanine ammonia-lyases.;Taylor R G, Lambert M A, Sexsmith E, Sadler S J, Ray P N, Mahuran D J, McInnes R R, ;1990;The Journal of biological chemistry;265;18192-9; 2120224
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archivingheterozygous 0, heterozygous 0
Breeding at archiving centreProduced by crossing homozygous males vs females, or heterozygous males vs females.
Stage of embryos8-cell

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • increased urine histidine level / MGI

Literature references

  • Histidinaemia in mouse and man.;Bulfield G, Kacser H, ;1974;Archives of disease in childhood;49;545-52; 4546820
  • Histidinemia in mice: a metabolic defect treated using a novel approach to hepatocellular transplantation.;Selden C, Calnan D, Morgan N, Wilcox H, Carr E, Hodgson H J, ;1995;Hepatology (Baltimore, Md.);21;1405-12; 7537713
  • Assignment of histidase-regulating locus to chromosome 10 of the mouse.;Arfin S M, Hanford W C, Taylor B A, ;1979;Biochemical genetics;17;529-35; 518536
  • Histidase and histidinemia. Clinical and molecular considerations.;Taylor R G, Levy H L, McInnes R R, ;1991;Molecular biology & medicine;8;101-16; 1943682
  • Localization of histidase to human chromosome region 12q22----q24.1 and mouse chromosome region 10C2----D1.;Taylor R G, García-Heras J, Sadler S J, Lafreniere R G, Willard H F, Ledbetter D H, McInnes R R, ;1991;Cytogenetics and cell genetics;56;178-81; 2055114
  • Cloning and expression of rat histidase. Homology to two bacterial histidases and four phenylalanine ammonia-lyases.;Taylor R G, Lambert M A, Sexsmith E, Sadler S J, Ray P N, Mahuran D J, McInnes R R, ;1990;The Journal of biological chemistry;265;18192-9; 2120224

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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